| 主要業績 |
- 総説: 松岡 由和、薗田 精昭。ヒト臍帯血由来造血幹細胞の陽性分子マーカーとしてのGPI-80抗原の有用性。Cytometry Research, 28 (2):13-17, 2018.
- Matsuoka Y, Sumide K, Sonoda Y. One-year Observation of the SCID-repopulating Cell Activities of Human Cord Blood-derived CD34-positive and -negative Hematopoietic Stem Cells. Stem Cell Reviews and Reports, in press.
- 薗田 精昭: ヒト造血幹細胞の最新知見 –ヒト造血幹細胞の純化と階層制の解明-。Updated human hematopoietic stem cell findings: purification of human hematopoietic stem cells and elucidation of their hierarchy. 臨床血液 59:1-11 (2018)
- Matsuoka Y, Nakamura F, Hatanaka K, Fujioka T, Otani S, Kimura T, Fujimura Y, Asano H and Sonoda Y, The number of CD34+CD133+ hematopoietic stem cell residing in umbilical cord blood (UCB) units is not correlated with the number of total nucreated cells and CD34+ cells: A possible new indicator for quality evaluation of UCB units., International Journal of Hematology, DOI: 10.1007/s12185-018-2502-7 ,2018
- Sumide K, Matsuoka Y, Kawamura H, Nakatsuka R, Fujioka T, Asano H, Takihara Y and Sonoda Y, A Rivised Road Map for the Comittment of Human Cord Blood CD34-negative Hematopoietic Stem Cells, Nature Communications, 9(1):2202,2018
- Kawamura H, Nakatsuka R, Matsuoka Y, Sumide K, Fujioka T, Asano H, Iida H and Sonoda Y, TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells, Stem Cell Reports, 10(3):920-32,2018
- Abe T, Matsuoka Y, Nagao Y, Sonoda Y*, Hanazono Y*. CD34-negative hematopoietic stem cells show distinct expression profiles of homing molecules that limit engraftment in mice and sheep. Int J Hematol, 106:631-637, 2017. *Co-corresponding author.
- Matsuoka Y, Takahashi M, Sumide K, Kawamura H, Nakatsuka R, Fujioka T, Sonoda Y: CD34 Antigen and the MPL Receptor Expression Defines A Novel Class Of Human Cord Blood-Derived Primitive Hematopoietic Stem Cells. Cell Transplant 26(6):1043-1058,2017.
- Sonoda Y: Human Hematopoietic Stem Cells: The Current Understanding and Future Prospects. Journal of Hematopoietic Cell Transplantation 6(2):70-83,2017.
- Matsuoka Y, Sumide K, Kawamura H, Nakatsuka R, Fujioka T, Sonoda Y: GPI-80 expression highly purifies human cord blood-derived primitive CD34-negative hematopoietic stem cells. Blood 128(18):2258-2260, 2016.
- Nakatsuka R, Iwaki R, Matsuoka Y, Sumide K, Kawamura H, Fujioka T, Sasaki Y, Uemura Y, Asano H, Kwon A-Hon, Sonoda Y: Identification and Characterization of Lineage-CD45-Sca-1+ VSEL Phenotypic Cells Residing in Adult Mouse Bone Tissue. Stem Cells Dev 25(1):27-42,2016.
- Zhang R, Liu T-Y, Senju S, Haruta M, Hirosawa N, Suzuki M, Tatsumi M, Ueda N, Maki H, Nakatsuka R, Matsuoka Y, Sasaki Y, Tsuzuki S, Nakanishi H, Araki R, Abe M, Akatsuka Y, Sakamoto Y, Sonoda Y, Nishimura Y, Kuzushima K, Uemura Y： Generation of mouse pluripotent stem cell-derived proliferating myeloid cells as an unlimited source of functional antigen-presenting cells. Cancer Immunol Res, 3(6):668-677, 2015.
- Matsuoka Y, Nakatsuka R, Sumide K, Kawamura H, Takahashi M, Fujioka T, Uemura Y, Asano H, Sasaki Y, Inoue M, Ogawa H, Takahashi T, Hino M, Sonoda Y: Prospectively isolated human bone marrow cell-derived MSCs support primitive human CD34-negative hematopoietic stem cells. Stem Cells 33:1554-1565, 2015.
- Matsuoka Y, Sumide K, Kawamura H, Nakatsuka R, Fujioka T, Sasaki Y, Sonoda Y: Human cord blood-derived CD34-negative hematopoietic stem cells (HSCs) are myeloid-biased long-term repopulating HSCs. Blood Cance J , 5:e290;doi:10.1038/bcj. 2015.
- Nakatsuka R, Matsuoka Y, Uemura Y, Sumide K., Iwaki R, Takahashi M, Fujioka T, Sasaki Y, Sonoda Y. Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/progenitor cells in vitro. Cell Transplant, 24:97-113, 2015.
- Sonoda Y: Human CD34-negative hematopoietic stem cells. Book chapter in Ratajczak M, ed. “Adult Stem Cell Therapies : Alternatives to Plasticity”. Humana Press, Springer, Berlin, pp.53-77, 2014.
- Takahashi M, Matsuoka Y, Sumide K, Nakatsuka R, FujiokaT, Kohno H, Sasaki Y, Matsui K, Asano H, Kaneko K, Sonoda Y. CD133 is a Positive Marker for a Distinct Class of Primitive Human Cord Blood-derived CD34?negative Hematopoietic Stem Cells. Leukemia,28:1308-1315, 2014.
- Ishii M, Matsuoka Y, Sasaki Y, Nakatsuka R, Takahashi M, Nakamoto T, Yasuda K, Matsui K, Asano H, Uemura Y, Tsuji T, Fukuhara S, Sonoda Y. Development of a high-resolution purification method for precise functional characterization of primitive human cord blood-derived CD34-negative SCID-repopulating cells. Exp Hematol 39:203-213 2011.
- Matsuoka Y, Sasaki Y, Nakatsuka R, Takahashi M, Iwaki R, Uemura Y, Sonoda Y. The low level of c-kit expression marks deeply quiescent murine hematopoietic stem cells. Stem Cells 29:1783-1791,2011.
- Kimura T, Kohno H, Matsuoka Y, Murakami M, Nakatsuka R, Hase H, Yasuda K, Uemura Y, Sasaki Y, Fukuhara S, Sonoda Y. CXCL8 enhances the angiogenic activity of umbilical cord blood-derived outgrowth endothelial cells in vitro. Cell Biol Int 35:201-208,2011.
- Kimura T, Kohno H, Matsuoka Y, Nakatsuka R, Sasaki Y, Fukuhara S, Sonoda Y. CD16 antigen is a positive marker of peripheral blood-derived early endothelial progenitor cells. Int J Hematol 93:123-125,2011.
- Nakatsuka R, Nozaki T, Uemura Y, Matsuoka Y, Sasaki Y, Shinohara M, Ohura K, Sonoda Y. 5-Aza-2’-deoxycytidine treatment induces skeletal myogenic differentiation of mouse dental pulp stem cells. Arch Oral Biol 55:350-357, 2010
- Kimura T, Matsuoka Y, Murakami M, Kimura T, Takahashi M, Nakamoto T, Yasuda K, Matsui K, Kobayashi K, Imai S, Asano H, Nakatsuka R, Uemura Y, Sasaki Y, Sonoda Y. In vivo dynamics of human cord blood-derived CD34- SCID-repopulating cells using intra-bone marrow injection. Leukemia 24:162-168,2010.
- Sasaki Y, Matsuoka Y, Hase M, Toyohara T, Murakami M, Takahashi M, Nakatsuka R, Uemura Y, Sonoda Y. Marginal expression of CXCR4 on c-kit+Sca-1+Lineage- hematopoietic stem/progenitor cells. Int J Hematol 90:553-560,2009.
- Sonoda Y. Immunophenotype and functional characteristics of human primitive CD34-negative hematopoietic stem cells: The significance of the intra-bone marrow injection. J Autoimmun 30:136-144, 2008.
- Kimura T, Asada R, Wang J, Kimura T, Morioka M, Matsui K, Kobayashi K, Henmi K, Imai S, Kita M, Tsuiji T, Sasaki Y, Ikehara S, Sonoda Y. Identification of long-term repopulating potential of human cord blood-derived CD34-flt3- severe combined immunodeficiency- repopulating cells by intra-bone marrow injection. Stem Cells 25:1348-1355, 2007.
- Kimura T, Wang J, Matsui K, Imai S, Yokoyama S, Nishikawa M, Ikehara S, Sonoda Y. Proliferative and migratory potentials of human cord blood-derived CD34- severe combined immunodeficiency repopulating cells that retain secondary reconstituting capacity. Int J Hematol79:328-333,2004.
- Kimura T, Minamiguchi H, Wang J, Kaneko H, Nakagawa H, Fujii H, Sonoda Y. Impaired stem cell functions of CD34+ cells selected by two different immunomagnetic beads systems. Leukemia 18：566-574,2004.
- Wang J, Kimura T, Asada R, Harada S, Yokota S, Kawamoto Y, Fujimura Y, Tsuji T, Ikehara S, Sonoda Y. SCID-repopulating cell activity of human cord blood-derived CD34- cells assured by intra-bone marrow injection. Blood 101:2924-2931,2003. (Plenary paper)
- Fujiki H, Kimura T, Minamiguchi H, Harada S, Wang J, Nakao M, Yokota S, Urata Y, Ueda Y, Yamagishi H, Sonoda Y. Role of human interleukin-9 as a megakaryocyte potentiator in culture. Exp Hematol 30:1373-1380,2002.
- Minamiguchi H, Kimura T, Urata Y, Miyazaki H, Bamba T, Abe T, Sonoda Y. Simultaneous signaling through c-mpl, c-kit, and CXCR4 enhances the proliferation and differentiation of human megakaryocyte progenitors: possible roles of the PI3-K, PKC, and MAPK pathways. Br J Haematol 115:175-185, 2001.
- Minamiguchi H, Yahata N, Kimura T, Fujiki H, Harada S, Wang J, Okuda K, Kaneko H, Hodohara K, Banba T, Yasukawa K, Ohyashiki JH, Ohyashiki K, Abe T, Sonoda Y. Interleukin 6 receptor expression by human cord blood- or peripheral blood-derived primitive haematopoietic progenitors implies acquisition of different functional properties. Br J Haematol 110:327-338,2000.
- Kimura T, Wang J, Minamiguchi H, Fijiki H, Harada S, Okuda K, Kaneko H, Yokota S, Yasukawa K, Abe T, Sonoda Y. Signal through gp130 activated by soluble interleukin(IL)-6 receptor(R) and IL-6 or IL-6R/IL-6 fusion protein enhances ex vivo expansion of human peripheral blood-derived hematopoietic progenitors. Stem Cells 18:444-452,2000.
- Kimura T, Sakabe H, Minamiguchi H, Fujiki H, Abe T, Kaneko H, Yokota S, Nakagawa H, Fujii H, Tamaki H, Ogawa H, Sugiyama H, Sonoda Y. Inteleukin-11(IL-11) enhances clonal proliferation of acute myelogenous leukemia cells with strong expression of the IL-11 receptor α and signal transducing gp130. Leukemia 13:1018-1027,1999.
- Sakabe H, Kimura T, Zeng Z, Minamiguchi H, Tsuda S, Yokota S, Hodohara K, Abe T, Lyman SD, Sonoda Y. Haematopoietic action of flt3 ligand on cord blood-derived CD34-positive cells expressing different levels of flt3 or c-kit tyrosine kinase receptor: comparison with stem cell factor. Eur J Haematol 60: 297-306, 1998.
- Sakabe H, Yahata N, Kimura T, Zeng ZZ, Minamiguchi H, Kaneko H, Mori KJ, Ohyashiki K, Ohyashiki JH, Toyama K, Abe T, Sonoda Y. Human cord blood-derived primitive progenitors are enriched in CD34+c-kit- cells: correlation between long-term culture-initiating cells and telomerase expression. Leukemia 12:728-734,1998.
- Sakabe H, Ohmizono Y, Tanimukai S, Kimura T, Mori KJ, Abe T, Sonoda Y. Functional differences between subpopulations of mobilized peripheral blood-derived CD34+ cells expressing different levels of HLA-DR, CD33, CD38, and c-kit antigens. Stem Cells 15:73-81,1997.
- Sonoda Y, Kimura T, Ohmizono Y, Sakabe H, Tanimukai S, Yokota S, Clark SC, Abe T.: Action of human interleukin-4 and stem cell factor on erythroid and mixed colony formation by peripheral blood-derived CD34+c-kithigh or CD34+c-kitlow cells. Br J Haematol 96:781-789, 1997.
- Ohmizono Y, Sakabe H, Kimura T, Tanimukai S, Matsumura T, Miyazaki H, Lyman SD, Sonoda Y. Thrombopoietin augments ex vivo expansion of human cord blood-derived hematopoietic progenitors in combination with stem cell factor and flt3 ligand. Leukemia 11: 524-530, 1997.
- Sonoda Y, Kimura T, Sakabe H, Tanimukai S, Ohmizono Y, Nakagawa S, Yokota S, Lyman SD, Abe T. Human flt3 ligand acts on myeloid as well as multipotential progenitors derived from purified CD34+ blood progenitors expressing different levels of c-kit protein. Eur J Haematol 58: 257-264,1997.
- Tanimukai S, Kimura T, Sakabe H, Ohmizono Y, Kato T, Miyazaki H, Yamagishi H, Sonoda Y. Recombinant human c-Mpl ligand(thrombopoietin) not only acts on megakaryocyte progenitors, but also on erythroid and multipotential progenitors in vitro. Exp Hematol 25:1025-1033,1997.
- Kimura T, Sakabe H, Tanimukai S, Abe T, Urata Y, Yasukawa K, Okano A, Taga T, Sugiyama H, Kishimoto T, Sonoda Y. Simultaneous activation of signals through gp130, c-kit, and interleukin-3 receptor promotes a trilimeage blood cell production in the absence of terminally acting lineage-specific factors. Blood 90:4767-4778, 1997.
- Ariyama Y, Misawa S, Sonoda Y. Synergistic effects of stem cell factor and interleukin 6 or interleukin 11 on the expansion of murine hematopoietic progenitors in liquid suspension culture. Stem Cells 13: 404-413, 1995.
- Sonoda Y, Sakabe H, Ohmisono Y, Tanimukai S, Yokota S, Nakagawa S, Clark SC, Abe T. Synergistic actions of stem cell factor and other burst-promoting activities on proliferation of CD34+ highly purified blood progenitors expressing HLA-DR or different levels of c-kit protein. Blood 84:4099-4106,1994.
- Sonoda Y, Kuzuyama Y, Tanaka S, Yokota S, Maekawa T, Clark SC, Abe T.: Human interleukin-4 inhibits proliferation of megakaryocyte progenitor cells in culture. Blood 81:624-630,1993.
- Sonoda Y, Okuda T, Yokota S, Maekawa T, Shizumi Y, Nishigaki N, Misawa S, Fujii H, Abe T. Actions of human interleukin-4/B-cell stimulatory factor-1 on proliferation and differentiation of enriched hematopoietic progenitor cells in culture. Blood 75:1615-1621,1990.
- Sonoda Y, Arai N, Ogawa M. Humoral regulation of eosinophilopoiesis in vitro: Analysis of the targets of interleukin-3, granulocyte/macrophage colony- stimulating factor (GM-CSF) and interleukin-5. Leukemia 3:14-18, 1989.
- Sonoda Y, Ogawa M. Serum-free culture of human hemopoietic progenitors in attenuated culture media. Am. J. Hematol 28:227-231,1988.
- Sonoda Y, Yang Y-C, Wong GG, Clark SC, Ogawa M. Erythroid burst-promoting activity of purified recombinant human GM-CSF and Interleukin-3:Studies with anti-GM-CSF and anti-IL-3 sera and studies in serum-free cultures. Blood 72: 1381-1386,1988.
- Sonoda Y, Yang Y-C, Wong GG, Clark SC, Ogawa M.: Analysis in serum-free culture of the targets of recombinant human hemopoietic factors:Demonstration that interleukin-3 and granulocyte/ macrophage colony-stimulating factors are specific for early developmental stages. Proc Natl Acad Sci USA 85:4360-4364,1988.
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