主要業績
-原著論文/基礎- |
- Okano M, Yasuda M, Shimomura Y, Matsuoka Y, Shirouzu Y, Fujioka T, Kyo M, Tsuji S, Kaneko K, Hitomi H,: Citrin-deficient patient-derived induced pluripotent stem cells as a pathological liver model for congenital urea cycle disordersMol Genet Metab Rep 2024;40:101096. [Link]
- Katagiri N, Hitomi H, Mae S, Kotaka M, Lei L, Yamamoto T, Nishiyama A, Osafune K.: Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived erythropoietin-producing cells. Scientific reports 2021;11(1):3936.[Link]
- Nishimoto S, Mizuno T, Takahashi K, Nagano F, Yuzawa Y, Nishiyama A, Osafune K, Hitomi H, Nagamatsu T.: CD140b and CD73 are markers for human induced pluripotent stem cell‐derived erythropoietin‐producing cells. FEBS Open bio 10;427-433 2020. [link]
- Yamazaki D, Konishi Y, Morikawa T, Kobara H, Masaki T, Hitomi H, Osafune K, Nakano D, Kittikulsuth W, Nishiyama A.: Failure to confirm an SGLT2 inhibitor-induced hematopoietic effect in non-diabetic rats with renal anemia. J Diabetes Investig 2019;11(4):834-43..[Link]
- Zhang Y, Nakano D, Guan Y, Hitomi H, Uemura A, Masaki T, Kobara H, Sugaya T, Nishiyama A: A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice. Kidney International 94(3):524-535, 2018.[Link]
- Wan N, Rahman A, Hitomi H, Nishiyama A: The Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Sympathetic Nervous Activity. Frontiers in Endocrinology 26;9:421, 2018.
- Li L, Konishi Y, Morikawa T, Zhang Y, Kitabayashi C, Kobara H, Masaki T, Nakano D, Hitomi H, Kobori H, Nishiyama A: Effects of an SGLT2 inhibitor on the systemic and intrarenal renin-angiotensin system in subtotally nephrectomized rats. Journal of Pharmacological Sciences 137:220-3, 2018.
- Rahman A, Yamazaki D, Sufiun A, Kitada K, Hitomi H, Nakano D, Nishiyama A.: A novel approach to adenine-induced chronic kidney disease associated anemia in rodents. PLoS One 13:e0192531, 2018.
- Hitomi H, Kasahara T, Katagiri N, Hoshina A, Mae S, Kotaka M, Toyohara T, Rahman A, Nakano D, Niwa A, Saito M, Nakahata T, Nishiyama A, Osafune K.: Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice. Science Translational Medicine 9:409, 2017.
- Ansary TM, Fujisawa Y, Rahman A, Nakano D, Hitomi H, Kobara H, Masaki T, Titze JM, Kitada K, Nishiyama A.: Responses of renal hemodynamics and tubular functions to acute sodium-glucose cotransporter 2 inhibitor administration in non-diabetic anesthetized rats. Scientific Reports 7:9555, 2017.
- Rahman A, Fujisawa Y, Nakano D, Hitomi H, Nishiyama A.: Effect of a selective SGLT2 inhibitor, luseogliflozin, on circadian rhythm of sympathetic nervous function and locomotor activities in metabolic syndrome rats. Clinical and Experimental Pharmacology and Physiology 44:522-5, 2017.
- Hasan AU, Kittikulsuth W, Yamaguchi F, Ansary TM, Rahman A, Shibayama Y, Nakano D, Hitomi H, Tokuda M, Nishiyama A.: IBMX protects human proximal tubular epithelial cells from hypoxic stress through suppressing hypoxia-inducible factor-1α expression. Experimental Cell Research 358:343-51, 2017.
- Guan Y, Nakano D, Zhang Y, Li L, Liu W, Nishida M, Kuwabara T, Morishita A, Hitomi H, Mori K, Mukoyama M, Masaki T, Hirano K, Nishiyama A.: A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy. Journal of Pharmacological Sciences 135:81-8, 2017.
- Li L, Konishi Y, Morikawa T, Zhang Y, Kitabayashi C, Kobara H, Masaki T, Nakano D, Hitomi H, Kobori H, Nishiyama A.: Effects of an SGLT2 inhibitor on the systemic and intrarenal renin-angiotensin system in subtotally nephrectomized rats. Journal of Pharmacological Sciences 2017 in press.
- Rahman A, Kittikulsuth W, Fujisawa Y, Sufiun A, Rafiq K, Hitomi H, Nakano D, Sohara E, Uchida S, Nishiyama A.: Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome. Journal of Hypertension 34:893-906, 2016.
- Morita T, Nakano D, Kitada K, Morimoto S, Ichihara A, Hitomi H, Kobori H, Shiojima I, Nishiyama A.: Chelation of dietary iron prevents iron accumulation and macrophage infiltration in the type I diabetic kidney. European Journal of Pharmacology 756:85-91, 2015.
- Liu G, Hitomi H, Rahman A, Nakano D, Mori H, Masaki T, Ma H, Iwamoto T, Kobori H, Nishiyama A.: High sodium augments angiotensin II-induced vascular smooth muscle cell proliferation through ERK 1/2- dependent pathway. Hypertension Research 37:13-8, 2014.
- Rafiq K, Fan YY, Sherajee SJ, Takahashi Y, Matsuura J, Hase N, Mori H, Nakano D, Kobara H, Hitomi H, Masaki T, Urata H, Nishiyama A.: Chymase activities and survival in endotoxin-induced human chymase transgenic mice. International Journal of Medical Sciences 11:222-5, 2014.
- Yasuno T, Osafune K, Sakurai H, Asaka I, Tanaka A, Yamaguchi S, Yamada K, Hitomi H, Arai S, Kurose Y, Higaki Y, Sudo M, Ando S, Nakashima H, Saito T, Kaneoka H.: Functional analysis of iPSC-derived myocytes from a patient with carnitine palmitoyltransferase II deficiency. Biochemical and Biophysical Research Communications 448:175-81, 2014.
- Kitada K, Nakano D, Ohsaki H, Hitomi H, Minamino T, Yatabe J, Felder RA, Mori H, Masaki T, Kobori H, Nishiyama A.: Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. Journal of Diabates Complications 28:604-11, 2014.
- Shibayama Y, Hitomi H, Nakano D, Kobori H, Mori H, Deguchi K, Masaki T, Ichihara A, Nishiyama A.: Role of (pro)renin receptor in angiotensin II-dependent and -independent EGF receptor transactivation. Frontiers of Bioacience E5:697-705, 2013.
- Fan YY, Kobori H, Nakano D, Hitomi H, Mori H, Masaki T, Sun YX, Zhang L, Huang W, Zhu B, Li P, Nishiyama A.: Aberrant activation of the intrarenal renin-angiotensin system in the developing kidneys of type 2 diabetic rats. Hormone Metabolism Research 45:338-43, 2013.
- Kosaka S, Pelish N, Rahman M, Nakano D, Hitomi H, Kobori H, Fukuoka N, Kobara H, Mori H, Masaki T, Cervenka L, Matsumura Y, Houchi H, Nishiyama A.: Effects of angiotensin II AT1 receptor blockade on high fat diet-induced vascular oxidative stress and endothelial dysfunction in Dahl salt-sensitive rats. Journal of Pharmacological Sciences 121:95-102, 2013.
- Ohnishi K, Murase M, Nakano D, Pelisch N, Hitomi H, Kobori H, Morimoto S, Mori H, Masaki T, Ohmori K, Kohno M, Ichihara A, Nishiyama A.: Angiotensin-Converting Enzyme Inhibitor Does Not Suppress Renal Angiotensin II Levels in Angiotensin I-Infused Rats. Journal of Pharmacological Sciences 122:103-8, 2013.
- Liu Y, Hitomi H, Diah S, Deguchi K, Mori H, Masaki T, Nakano D, Kobori H, Nishiyama A.: Roles of Na+/H+ Exchanger Type 1 and Intracellular pH in Angiotensin II-Induced Reactive Oxygen Species Generation and Podocyte Apoptosis. Journal of Pharmacological Sciences 122:176-83, 2013.
- Sherajee SJ, Rafiq K, Nakano D, Mori H, Kobara H, Hitomi H, Fujisawa Y, Kobori H, Masaki T, Nishiyama A.: Aldosterone aggravates glucose intolerance induced by high fructose. European Journal of Pharmacology 720:63-8, 2013.
- Rafiq K, Sherajee SJ, Hitomi H, Nakano D, Kobori H, Ohmori K, Mori H, Kobara H, Masaki T, Kohno M, Nishiyama A.: Calcium channel blocker enhances beneficial effects of an angiotensin II AT1 receptor blocker against cerebrovascular-renal injury in type 2 diabetic mice. PLoS One 8:e82082, 2013.
- Sherajee SJ, Fujita Y, Rafiq K, Nakano D, Mori H, Masaki T, Hara T, Kohno M, Nishiyama A, Hitomi H.: Aldosterone Induces Vascular Insulin Resistance by Increasing Insulin-Like Growth Factor-1 Receptor and Hybrid Receptor. Arteriosclerosis, Thrombosis, and Vascular Biology 32:257-63, 2012.
- Nakano D, Lei B, Kitada K, Hitomi H, Kobori H, Mori H, Deguchi K, Masaki T, Minamino T, Nishiyama A.: Aldosterone does not contribute to renal p21 expression during the development of angiotensin II-induced hypertension in mice. American Journal of Hypertension 25:354-8, 2012.
- Sofue T, Kiyomoto H, Kobori H, Urushihara M, Nishijima Y, Kaifu K, Hara T, Matsumoto S, Ichimura A, Ohsaki H, Hitomi H, Kawachi H, Hayden MR, Whaley-Connell A, Sowers JR, Ito S, Kohno M, Nishiyama A.: Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats. American Journal of Hypertension 25:604-11, 2012.
- Rafiq K, Noma T, Fujisawa Y, Ishihara Y, Arai Y, Navi AHMN, Suzuki F, Nakano D, Hitomi H, Kitada K, Urushihara M, Kobori H, Kohno M, Nishiyama A.: Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation. Circulation 125:1402-13, 2012.
- Lei B, Nakano D, Fan YY, Kitada K, Hitomi H, Kobori H, Mori H, Masaki T, Nishiyama A.: Add-On Aliskiren Elicits Stronger Renoprotection Than High-Dose Valsartan in Type 2 Diabetic KKAy Mice That Do Not Respond to Low-Dose Valsartan. Journal of Pharmacological Sciences 119:131-8, 2012.
- Lei B, Nakano D, Fujisawa Y, Liu Y, Hitomi H, Kobori H, Mori H, Masaki T, Asanuma K, Tomino Y, Nishiyama A.: N-type calcium channel inhibition with cilnidipine elicits glomerular podocyte protection independent of sympathetic nerve inhibition. Journal of Pharmacological Sciences 119:359-67, 2012.
- Kitada K, Nakano D, Liu Y, Fujisawa Y, Hitomi H, Shibayama Y, Shibata H, Nagai Y, Mori H, Masaki T, Kobori H, Nishiyama A.: Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats. PLoS One 7:e41896, 2012.
- Nakano D, Kobori H, Burford JL, Gevorgyan H, Seidel S, Hitomi H, Nishiyama A, Peti-Peterdi J.: Multiphoton Imaging of the Glomerular Permeability of Angiotensinogen. Journal of the American Society of Nephrology 23:1847-56, 2012.
- Kitada K, Nakano D, Hitomi H, Kobori H, Deguchi K, Mori H, Masaki T, Nishiyama A.: Aldosterone induces p21-regulated apoptosis via increased synthesis and secretion of tumour necrosis factor-α in human proximal tubular cells. Clinical and Experimental Pharmacology and Physiology 39:858-63, 2012.
- Hitomi H, Kaifu K, Fujita Y, Sofue T, Nakano D, Moriwaki K, Hara T, Kiyomoto H, Kohno M, Kobori H, Nishiyama A.: Angiotensin II shifts insulin signaling into vascular remodeling from glucose metabolism in vascular smooth muscle cells. American Journal of Hypertension 24:1149-55, 2011.
- Hitomi H, Mehta PK, Taniyama Y, Lassègue B, Seidel-Rogol B, San Martin A, Griendling KK.: Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of Angiotensin II-induced IRS-1 phosphorylation by JNK. American Journal of Physiology-Cell Physiology 301:C1415-22, 2011.
- Liu G, Hitomi H, Nosomi N, Shibayama Y, Nakano D, Kiyomoto H, Ma H, Yamaji Y, Kohno M, Ichihara A, Itoh H, Nishiyama A.: Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via EGF receptor-mediated ERK and Akt activation pathway. Journal of Hypertension 29:696-705, 2011.
- Liu G, Hitomi H, Hosomi N, Lei B, Nakano D, Deguchi K, Mori H, Masaki T, Ma H, Griendling KK, Nishiyama A.: Mechanical stretch augments insulin-induced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor. Experimental Cell Research 317:2420-8, 2011.
- Lei B, Hitomi H, Mori T, Nagai Y, Deguchi K, Mori H, Masaki T, Nakano D, Kobori H, Kitaura Y, Nishiyama A.: Effect of Efonidipine on TGF-β1-Induced Cardiac Fibrosis Through Smad2-Dependent Pathway in Rat Cardiac Fibroblasts. Journal of Pharmacological Sciences 117:98-105, 2011.
- Rafiq K, Nakano D, Hitomi H, Ihara G, Nagai Y, Fujisawa Y, Ohashi N, Kobori H, Kiyomoto H, Kohno M, Nishiyama A.: Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats. Journal of Hypertension 29:290-8, 2011.
- Liu G, Hosomi N, Hitomi H, Pelish N, Fu H, Masugata H, Murao K, Ueno M, Matsumoto M, Nishiyama A.: Angiotensin II induces human astrocyte senescence via reactive oxygen species production. Hypertension Research 34:479-83, 2011.
- Pelisch N, Hosomi N, Ueno M, Nakano D, Hitomi H, Mogi M, Shimada K, Kobori H, Horiuchi M, Sakamoto H, Matsumoto M, Kohno M, Nishiyama A.: Blockade of angiotensin II AT1 receptors protects the blood brain barrier and cognition in Dahl salt-sensitive hypertensive rats. American Journal of Hypertension 24:362-8, 2011.
- Fan YY, Kohno M, Hitomi H, Kitada K, Fujisawa Y, Yatabe J, Yatabe M, Felder RA, Ohsaki H, Rafiq K, Sherajee SJ, Noma T, Nishiyama A, Nakano D.: Aldosterone/Mineralocorticoid receptor stimulation induces cellular senescence in the kidney. Endocrinology 152:680-8, 2011.
- Rafiq K, Sherajee SJ, Fan YY, Fujisawa Y, Takahashi Y, Matsuura J, Hase N, Urata H, Nakano D, Hitomi H, Nishiyama A.: Blood glucose level and survival in streptozotocin-treated human chymase transgenic mice. Chinese Journal of Physiology 54:30-5, 2011.
- Fujisawa Y, Nagai Y, Lei B, Nakano D, Fukui T, Hitomi H, Mori H, Masaki T, Nishiyama A.: Roles of central renin-angiotensin system and afferent renal nerve in the control of systemic hemodynamics in rats. Hypertension Research 34:1228-32, 2011.
- Rafiq K, Hitomi H, Nakano D, Ichihara A, Nishiyama A.: Possible involvement of the (pro)renin receptor-dependent system in the development of insulin resistance. Frontiers of Bioscience 3:1478-85, 2011.
- Nakano D, Diah S, Kitada K, Hitomi H, Mori H, Masaki T, Kobori H, Nishiyama A.: Short-term calorie restriction in early life attenuates the development of proteinuria but not glucose intolerance in type 2 diabetic OLETF rats. ISRN Endocrinology 2011:768637, 2011.
- Liu G, Miyata K, Hitomi H, Yao L, Sun GP, Suzaki Y, Hosomi N, Kiyomoto H, Nakano D, Tamaki T, Yoshizumi M, Nishiyama A.: Involvement of mineralocorticoid receptor in high glucose–induced BMK1 activation and mesangial cell proliferation. Journal of Hypertension 28:536-42, 2010.
- Liu G, Hitomi H, Hosomi N, Lei B, Pelisch N, Nakano D, Kiyomoto K, Ma H, Nishiyama A.: Mechanical stretch potentiates angiotensin II-induced proliferation in spontaneously hypertensive rat vascular smooth muscle cells. Hypertension Research 33:1250-7, 2010.
- Nishiyama A, Kobori H, Konishi Y, Morikawa T, Maeda I, Okumura M, Kishida M, Hamada M, Nagai Y, Nakagawa T, Ohashi N, Nakano D, Hitomi H, Imanishi M.: Mineralocorticoid receptor blockade enhances the anti-proteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats. Journal of Pharmacology and Experimental Therapietics 332:1072-80, 2010.
- Pelisch N, Hosomi N, Ueno M, Masugata H, Murao K, Hitomi H, Nakano D, Kobori H, Nishiyama A, Kohno M.: Systemic candesartan reduces brain angiotensin II via downregulation of brain renin-angiotensin system. Hypertension Research 33:161-4, 2010.
- Fan YY, Kohno M, Nakano D, Ohsaki H, Kobori H, Suwarni D, Ohashi N, Hitomi H, Asanuma K, Noma T, Tomino Y, Fujita T, Nishiyama A.: Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte. Journal of Hypertension 28:1034-43, 2010.
- Ihara G, Kiyomoto H, Kobori H, Nakai Y, Ohashi N, Hitomi H, Nakano D, Pelisch N, Hara T, Mori T, Ito S, Kohno M, Nishiyama A.: Regression of superficial glomerular podocyte injury in type 2 diabetic rats with overt albuminuria: effect of angiotensin II blockade. Journal of Hypertension 28:2289-98, 2010.
- Fan Y, Kohno M, Nakano D, Hitomi H, Nagai Y, Fujisawa Y, Lu XM, Fu K, Du J, Ohmori K, Hosomi N, Kimura S, Kiyomoto H, Nishiyama.: Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats. Journal of Hypertension 27:1855-62, 2009.
- Du J, Fan YY, Hitomi H, Kiyomoto H, Kimura S, Kong CZ, Noma T, Kohno M, Nishiyama A, Nakano D.: Mineralocorticoid receptor blockade and calcium channel blockade have different renoprotective effects on glomerular and interstitial injury in rats. American Journal of Physiology and Renal Physiology 297:F802-8, 2009.
- Kaifu K, Kiyomoto H, Hitomi H, Matsubara K, Hara T, Moriwaki K, Ihara G, Fujita Y, Sugasawa N, Nagata D, Nishiyama A, Kohno M.: Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells. Nephrology Dialysis and Transplantation 24:809-815, 2009.
- Nagai Y, Ichihara A, Nakano D, Kimura S, Pelisch N, Fujisawa Y, Hitomi H, Hosomi N, Kiyomoto H, Kohno M, Ito H, Nishiyama A.: Possible contribution of the non-proteolytic activation of prorenin to the development of insulin resistance in fructose-fed rats. Experimental physiology 94:1016-23, 2009.
- Fan YY, Nishiyama A, Fujisawa Y, Kobori H, Nakano D, Matsuura J, Hase N, Hitomi H, Kiyomoto H, Urata H, Kohno M.: Contribution of chymase-dependent angiotensin II formation to the progression of tubulointerstitial fibrosis in obstructed kidneys in hamsters. Journal of Pharmacological Sciences 111:82-90, 2009.
- Diah S, Zhang GX, Nagai Y, Zhang W, Gang L, Kimura S, Hamid MR, Tamiya T, Nishiyama A, Hitomi H.: Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through Rho-kinase dependent signaling pathway in rat mesangial cells. Experimental Cell Research 314:3654-62, 2008.
- Miyata K, Hitomi H, Guo P, Zhang GX, Kimura S, Kiyomoto H, Hosomi N, Kagami S, Kohno M, Nishiyama A.: Possible involvement of Rho-kinase in aldosterone-induced vascular remodeling. Hypertension Research 31:1407-13, 2008.
- Hitomi H, Kiyomoto H, Nishiyama A, Hara T, Moriwaki K, Kaifu K, Ihara G, Fujita Y, Ugawa T, Kohno M.: Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells. Hypertension 50:750-5, 2007.
- Kondo N, Kiyomoto H, Yamamoto T, Miyatake A, Sun GP, Rahman M, Hitomi H, Moriwaki K, Hara T, Kimura S, Abe Y, Kohno M, Nishiyama A.: Effects of calcium channel blockade on angiotensin II-induced peritubular ischemia in rats. Journal of Pharmacology and Experimenta Therapeutics 316:1047-52, 2006.
- Hitomi H, Fukui T, Moriwaki K, Matsubara K, Sun GP, Rahman M, Nishiyama A, Kiyomoto H, Kimura S, Ohmori K, Abe Y, Kohno M.: Synergistic effect of mechanical stretch and angiotensin II on superoxide production via NADPH oxidase in vascular smooth muscle cells. Journal of Hypertension 24:1097-104, 2006.
- Moriwaki K, Kiyomoto H, Hitomi H, Ihara G, Kaifu K, Matsubara K, Hara T, Kondo N, Ohmori K, Nishiyama A, Fukui T, Kohno M.: Interferon-γ enhances superoxide production in human mesangial cells via the JAK-STAT pathway. Kidney International 70:788-93, 2006.
- Taniyama Y, Hitomi H, Shah A, Alexander RW, Griendling KK.: Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II. Arteriosclerosis, Thrombosis, and Vascular Biology 25:1142-7, 2005.
- Taniyama Y, Ushio-Fukai M, Hitomi H, Rocic P, Kingsley MJ, Pfahnl C, Weber DS, Alexander RW, Griendling KK.: Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells. American Journal of Physiology and Cell Physiology 287:C494-9, 2004.
- Matsubara K, Kiyomoto H, Moriwaki K, Hara T, Kondo N, Shokoji T, Hitomi H, Aki Y, Aono M, Nishiyama A, Ohmori K, Kohno M.: Leptin kinetics during peritoneal dialysis in acutely uraemic rats. Nephrology 9:256-61, 2004.
- Nishiyama A, Yoshizumi M, Rahman M, Kobori H, Seth DM, Miyatake A, Zhang GX, Yao L, Hitomi H, Shokoji T, Kiyomoto H, Kimura S, Tamaki T, Kohno M, Abe Y.: Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats. Kidney International 65:972-81, 2004.
- Nishiyama A, Yoshizumi M, Hitomi H, Kagami S, Kondo S, Miyatake A, Fukunaga M, Tamaki T, Kiyomoto H, Kohno M, Shokoji T, Kimura S, Abe Y.: The SOD mimetic tempol ameliorates glomerular injury and reduces mitogen-activated protein kinase activity in Dahl salt-sensitive rats. Journal of American Society of Nephrology 15:306-15, 2004.
- Rahman M, Kimura S, Nishiyama A, Hitomi H, Zhang G, Abe Y.: Angiotensin II stimulates superoxide production via both angiotensin AT1A and AT1B receptors in mouse aorta and heart. European Journal of Pharmacology 485:243-9, 2004.
- Nishiyama A, Kobori H, Fukui T, Zhang GX, Yao L, Rahman M, Hitomi H, Kiyomoto H, Shokoji T, Kimura S, Kohno M, Abe Y.: Role of angiotensin II and reactive oxygen species in cyclosporine A-dependent hypertension. Hypertension 42:754-60, 2003.
- Shokoji T, Nishiyama A, Fujisawa Y, Hitomi H, Kiyomoto H, Takahashi N, Kimura S, Kohno M, Abe Y.: Renal sympathetic nerve responses to tempol in spontaneously hypertensive rats. Hypertension 41:266-73, 2003.
- Yuasa S, Li X, Hitomi H, Hashimoto M, Fujioka H, Kiyomoto H, Uchida K, Shoji T, Takahashi N, Miki S, Miyatake A, Mizushige K, Matsuo H.: Sodium sensitivity and sympathetic nervous system in hypertension induced by long-term nitric oxide blockade in rats. Clinical and Experimental Pharmacology and Physiology 27:18-24, 2000.
- Hitomi H, Kiyomoto H, Hashimoto M, Aki Y, Uchida K, Takahashi N, Fukunaga M, Mizushige K, Senda S, Sakamoto H, Matsuo H, Yuasa S:. A new approach for glomerular lesions: evaluation of scanning acoustic microscopy (SAM) for experimental glomerular disease in rats. Ultrasound in Medicine & Biology 26:571-57, 2000.
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主要業績
-原著論文/臨床- |
- Miyashita T, Inamoto R, Fukuda S, Hoshikawa H, Hitomi H, Kiyomoto H, Nishiyama A, Mori N.: Hormonal changes following a low-salt diet in patients with Ménière's disease. Auris Nasus Larynx 44:52-7, 2017.
- Mizushige T, Kobori H, Hitomi H, Nishijima Y, Tomoda F, Morimoto S, Kohno M, Nishiyama A.: Urinary Angiotensinogen Could Be a Prognostic Marker of the Renoprotection of Olmesartan in Metabolic Syndrome Patients. International Journal of Molecular Science 17:1800, 2016.
- Nishijima Y, Kobori H, Sofue T, Kaifu K, Moriwaki K, Hara T, Hitomi H, Kohno M, Nishiyama A.: Important aspects of urine sampling for angiotensinogen measurement: time and preservation conditions in healthy individuals. Tohoku Journal of Experimental Medicine 228:333-9, 2012.
- Konishi Y, Nishiyama A, Morikawa T, Kitabayashi C, Shibata M, Hamada M, Kishida M, Hitomi H, Kiyomoto H, Miyashita T, Mori M, Urushihara M, Kobori H, Imanishi M.: Relationship between urinary angiotensinogen and salt sensitivity of blood pressure in patients with IgA nephropathy. Hypertension 58:205-11, 2011.
- Nishiyama A, Konishi Y, Ohashi N, Morikawa T, Urushihara M, Maeda I, Hamada M, Kishida M, Hitomi H, Shirahashi N, Kobori H, Imanishi M.: Urinary angiotensinogen reflects the activity of intrarenal renin-angiotensin system in patients with IgA nephropathy. Nephrology Dialysis Transplantation 26:170-7, 2011.
- Hara T, Kiyomoto H, Hitomi H, Moriwaki K, Ihara G, Kaifu K, Fujita Y, Higashiyama C, Nishiyama A, Kohno M.: Low-density lipoprotein apheresis for haemodialysis patients with peripheral arterial disease reduces reactive oxygen species production via suppression of NADPH oxidase gene expression in leucocytes. Nephrology Dialysis Transplantation 24:3818-25, 2009.
- Takahashi N, Yuasa S, Fukunaga M, Hara T, Moriwaki K, Shokoji T, Hitomi H, Fujioka H, Kiyomoto H, Aki Y, Hirohata M, Mizushige K, Kohno M.: Long-term evaluation of nutritional status using dual-energy X-ray absorptiometry in chronic hemodialysis patients. Clinical Nephrology 59:373-8, 2003.
- Hosotani Y, Takahashi N, Kiyomoto H, Ohmori K, Hitomi H, Fujioka H, Aki Y, Fukunaga M, Yuasa S, Mizushige K, Kohno M.: A new method for evaluation of split renal cortical blood flow with contrast echography. Hypertenstion Research 25:77-83, 2002.
- Takahashi N, Shoji T, Matsubara K, Hitomi H, Hashimoto M, Kiyomoto H, Uchida K, Miki S, Hirohata M, Ishizu T, Akiyama K, Mizushige K, Matsuo H, Yuasa S.: Effect of histamine H2-receptor antagonist on the phosphorus-binding abilities of calcium carbonate and calcium lactate in hemodialysis patients. The Journal of American Society of Nephology 10:1090-1094, 1999.
- Kiyomoto H, Hitomi H, Hosotani Y, Hashimoto M, Uchida K, Kurokouchi K, Nagai M, Takahashi N, Fukunaga M, Mizushige K, Matsuo H, Yuasa S.: The effect of combination therapy with interferon and cryofiltration on mesangial proliferative glomerulonephritis originating from mixed cryoglobulinemia in chronic hepatitis C virus infection. Therapeutic Apheresis 3:329-333, 1999.
- Yuasa S, Takahashi N, Shoji T, Uchida K, Kiyomoto H, Hashimoto M, Fujioka H, Hitomi H, Matsuo H.: A simple and early prognostic index for acute renal failure patients requiring renal replacement therapy. Artificial Organs 22:273-278, 1998.
- 東山智香子、清元秀泰、森脇久美子, 原大雅, 松原啓介, 人見浩史, 松向寺孝臣, 近藤直樹, 松本恵子, 横山るみ子, 河野雅和,: 慢性腎不全に非代償性肝硬変症を合併した難治性腹水に対する腹水濾過還元on-line血液透析療法の有用性の検討. 日本アフェレシス学会雑誌, 24:204-10, 2005.
- 高橋則尋, 福永恵, 森脇久美子, 原大雅, 松向寺孝臣, 細谷陽子, 人見浩史, 藤岡宏, 安岐康晴, 清元秀泰, 石津勉, 秋山賢次, 広畑衛, 河野雅和,: 維持透析患者におけるビタミンE固定化ダイアライザーを用いた酸化ストレス軽減作用に関する検討. 日本透析医会雑誌, 17:273-6, 2002.
- 高橋則尋, 原大雅, 森脇久美子, 松向寺孝臣, 細谷陽子, 人見浩史, 藤岡宏, 清元秀泰, 安岐康晴, 大森浩二, 福永惠, 湯浅繁一, 河野雅和,: 維持透析患者における後天性腎嚢胞に対する超音波造影法の診断能に関する検討. 日本透析医会雑誌, 16:196-9, 2001.
- 福永惠, 高橋則尋, 森脇久美子, 原大雅, 松向寺孝臣, 細谷陽子, 人見浩史, 藤岡宏, 清元秀泰, 石津勉, 秋山賢次, 広畑衛, 河野雅和,: 維持透析患者における酸化LDL分画を用いた酸化ストレスの検討－ダイアライザ－による比較－. 日本透析医会雑誌, 15:419-24, 2000.
- 湯淺繁一, 高橋則尋, 内田光一, 清元秀泰, 橋本真由子, 人見浩史, 福永恵,: 随時尿の蛋白/クレアチニン比を用いた蛋白尿の定量的評価. 香川県立医療短期大学紀要, 1:19-24, 1999.
- 高橋則尋, 松原啓介, 人見浩史, 橋本真由子, 清元秀泰, 内田光一, 松尾裕英, 湯浅繁一, 黒瀬高明, 半藤保,: 血液透析を併用したシスプラチン大量動注療法における腎毒性の軽減効果に関する検討. 日本アフェレシス学会雑誌, 17, 32, 1998.
- 高橋則尋, 湯浅繁一, 人見浩史, 橋本真由子, 清元秀泰, 内田光一, 広畑衛, 石津勉, 松尾裕英,: 身体学的計測および二重エネルギーX線吸収法による維持透析患者の栄養学的指標に関する検討. 日本透析医学会誌, 30:873-7, 1997.
- 李秀萍, 湯浅繁一, 人見浩史, 橋本真由子, 藤岡宏, 清元秀泰, 内田光一, 小路哲生, 高橋則尋, 松尾裕英,: Nitric oxide (NO) 合成慢性阻害時の血圧上昇機序に関する検討. 日本腎臓学会誌, 39:718-27, 1997.
- 高橋則尋, 湯淺繁一, 人見浩史, 橋本真由子, 清元秀泰, 内田光一, 小路哲生, 広畑衛, 松尾裕英,: 維持透析患者におけるリン吸着剤に及ぼすヒスタミンH2受容体遮断剤の影響に関する検討. 日本腎臓学会誌, 38:610-7, 1996.
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主要業績
-総説・著書- |
- Yamazaki D, Hitomi H, Nishiyama A.: Hypertension with diabetes mellitus “Complications”. Hypertension Research 41:147-56, 2018.
- Rahman A, Hitomi H, Nishiyama A.: Cardioprotective effects of SGLT2 inhibitors are possibly associated with normalization of the circadian rhythm of blood pressure. Hypertension Research 40:535-40, 2017.
- Hitomi H, Nishiyama A.: How should we treat patients with primary aldosteronism to prevent new-onset diabetes mellitus? Journal of Hypertensions. 35:1575-6, 2017.
- Rafiq K, Hitomi H, Nakano D, Nishiyama A.: Pathophysiological roles of aldosterone and mineralocorticoid receptor in the kidney. Journal of Pharmacological Sciences 115:1-7, 2011.
- Hitomi H, Liu G, Nishiyama A.: Role of (pro)renin receptor in cardiovascular cells from the aspect of signaling. Frontiers of Bioscience 2:1246-9, 2010.
- Nishiyama A, Hitomi H.: Role of caveolin and heat shock protein 70 interaction in the antioxidative effects of an angiotensin II type 1 receptor blocker in spontaneously hypertensive rats. Journal of Hypertensions 28:9-12, 2010.
- Mori T, Hitomi H, Nakamichi T, Miyata T, Sato H, Ito S.: A novel clinical biomarker for MPO-ANCA associated glomerulonephritis. Clinical and Experimental Pharmacology and Physiology 37:877-8, 2010.
- Nishiyama A, Hasegawa K, Diah S, Hitomi H.: New approaches to blockade of the Renin-Angiotensin-Aldosterone system: Mineralocorticoid receptor blockers exert antihypertensive and renoprotective effects independently of the renin-angiotensin system. Journal of Pharmacological Sciences 113:310-4, 2010.
- Nishiyama A, Hitomi H, Rahman A, Kiyomoto H.: Drug discovery for overcoming chronic kidney disease (CKD): pharmacological effects of mineralocorticoid-receptor blockers. Journal of Pharmacological Sciences 109:1-6, 2009.
- Hitomi H, Kiyomoto H, Nishiyama A.: Angiotensin II and oxidative stress. Current Opinion in Cardiology 22:311-5, 2007.
- Kiyomoto H, Hitomi H.: The Earlier, the Better. Hypertension Research 30:1-2, 2007.
- Jay D, Hitomi H, Griendling KK.: Oxidative stress and diabetic cardiovascular complications. Free Radical Biology & Medicine 40:183-92, 2006.
- 人見浩史, 長船健二, 西山成,: ヒトiPS細胞由来エリスロポエチン産生細胞. 腎・高血圧の最新治療, 5:69-73, 2016.
- 人見浩史, 長船健二,: iPS細胞からポドサイトへの分化. 腎と透析, 78:353-6, 2015.
- 人見浩史, 長船健二, 西山成,: 腎性貧血に対する未来医療. 腎・高血圧の最新治療, 3:100-4, 2014.
- 人見浩史, 長船健二,: ヒト腎臓再生への挑戦. 生体の科学, 65:244-8, 2014.
- 人見浩史, 長船健二, 西山成,: 医薬品の開発や適正使用へのiPS細胞技術の応用. 日本病院薬剤師会雑誌, 50:447-50, 2014.
- 北田研人, 中野大介, 人見浩史, 西山成,: アンジオテンシンII受容体拮抗薬. 薬局, 62:51-5, 2011.
- 人見浩史, 劉鋼, 中野大介, 西山成,: （プロ）レニン受容体を介した細胞内情報伝達系. 血管, 34:69-73, 2011.
- 西山成, 中野大介, 人見浩史,: カルシウム拮抗薬の抗酸化作用. Clinical Calcium, 20:38-44, 2010.
- 西山成, 中野大介, 人見浩史,: 腎とレニン・アンジオテンシン・アルドステロン系／高血圧. Pharma Medica, 28:29-33, 2010.
- 西山成, 中野大介, 人見浩史,: RAASとたんぱく尿. 腎臓, 32:190-5, 2010.
- 西山成, 人見浩史, 今西政仁, 小堀浩幸,: 慢性腎疾患患者における腎臓局所レニン・アンジオテンシン系の評価. 臨床薬理の進歩, 31:33-9, 2010.
- 原大雅, 清元秀泰, 森脇久美子, 西岡聡, 西島陽子, 祖父江理, 海部久美子, 人見浩史, 西山成, 河野雅和,: 腎不全合併末梢循環不全におけるLDLアフェレシスの有効性と白血球NAD(P)H oxidaseの関与. 腎とフリーラジカル, 10:169-75, 2010.
- 中野大介, 人見浩史, 西山成,: アルドステロンブロッカーの腎保護作用研究の最先端. 血圧, 17:512-4, 2010.
- 人見浩史, 西山成,: 抗アルドステロン薬の臓器保護効果. 医学のあゆみ, 228:567-72, 2009.
- 人見浩史,: アルドステロンによる腎細胞障害メカニズム. 臨床薬理, 40:47-8, 2009.
- 西山成, 中野大介, 人見浩史,: 血管作動性物質-生合成、分泌、生理作用-アルドステロン. 日本臨床, 67:188-93, 2009.
- 中野大介, 人見浩史, 西山成,: 尿細管老化にRAASは関与するか. Angiotensin Research, 6:257-62, 2009.
- 人見浩史, 西山成,: アルドステロンと臓器障害. 細胞, 40:314-7, 2008.
- 西山成, 人見浩史, 清元秀泰,: ミネラロコルチコイド受容体拮抗薬. 日本薬理学学会誌, 132:244-6, 2008.
- 人見浩史，小堀浩幸，西山成,: アンジオテンシノゲン. 腎と透析, 65:523-6, 2008.
- 西山成. 人見浩史, 河野雅和,: アルドステロンと臓器シグナル. 医学のあゆみ, 221:698-702, 2007.
- 西山成, 人見浩史, 清元秀泰,: アルドステロン研究の理解に必要な基礎知識（基礎編）. 医学のあゆみ, 221:805-8, 2007.
- 西山成, 人見浩史, 河野雅和,: これだけは知っておきたい分子腎臓学 2007. Aldosterone (renal injury). 腎と透析, 63:589-92, 2007.
- 人見浩史, 清元秀泰, 河野雅和、西山成,: アルドステロン依存性腎障害における酸化ストレス、MAPキナーゼ、Rhoキナーゼの役割. 内分泌・糖尿病科, 23:575-80, 2006.
- 人見浩史, 清元秀泰,: 腎機能検査と体液管理の実践. －腎疾患と水・電解質異常－ 医薬ジャーナル, 41:2752-6, 2005.
- 人見浩史, 清元秀泰, 内田光一, 高橋則尋, 福永惠, 湯浅繁一,: 薬剤性浮腫. 医学と薬学, 43:945-9, 2000.
- 湯浅繁一, 高橋則尋, 清元秀泰, 人見浩史,: アンジオテンシン・受容体拮抗薬. 医薬ジャーナル, 34:2185-90, 1998.
- 清元秀泰, 人見浩史, 湯浅繁一,: 尿比重. 綜合臨牀, 47:1253-5,1998.
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