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メンバー紹介
大学院生募集
戦略的創造研究推進事業 （ＣＲＥＳＴ）
「アレルギー・自己免疫領域」
新学術領域計画研究
「動く細胞と場のクロストークによる秩序の生成」
研究業績

  1. Kondo N, Ueda Y,Kita T, Ozawa M, Tomiyama T, Yasuda K, Lim DS, Kinashi T. NDR1-dependent regulation of kindlin-3 controls high-affinity LFA-1 binding and immune synapse organization. Mol Cell Biol. 2017 Jan 30. pii: MCB.00424-16. doi: 10.1128/MCB.00424-16.
  2. Katakai T, Kinashi T, Microenvironmental Control of High-Speed Interstitial T Cell Migration in the Lymph Node. Front Immunol. 2016 May 13;7:194. doi: 10.3389/fimmu.2016.00194. eCollection 2016.
  3. Ueda Y., Kondo N., Ozawa M., Tomiyama T., Yasuda K., Kinashi T., Sema3e/plexin D1 modulates immunological synapse and migration of thymocytes by Rap1 inhibition  J Immunol . 2016 Apr 1;196(7):3019-31. doi: 10.4049/jimmunol.1502121.
  4. Yasuda K., Ueda Y., Ozawa M., Matsuda T., Kinashi T., Enhanced cytotoxic T cell function and inhibition of tumor progression by Mst1 deficiency. FEBS Letter 590(1):68-75. (2016) doi: 10.1002/1873-3468.12045.
  5. Fukuhara T, Tomiyama T, Yasuda K, Ueda Y, Ozaki Y, Son Y, Nomura S, Uchida K, Okazaki K, Kinashi T. Hypermethylation of MST1 in IgG4-related autoimmune pancreatitis and rheumatoid arthritis.Biochem Biophys Res Commun. 2015 Aug 7;463(4):968-74. doi: 10.1016/j.bbrc.2015.06.043.
  6. Katakai T., Kondo N., Ueda Y., and Kinashi T., Autotaxin Produced by Stromal Cells Promotes LFA-1–Independent and Rho-Dependent Interstitial T Cell Motility. 2014;J Immunol 2014; 193:617-626; Prepublished online 16 June, (doi: 10.4049/jimmunol.1400565)
  7. Nishikimi A, Ishihara S, Ozawa M, Etoh K,Fukuda M, Kinashi T, Katagiri K. Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking. Sci. Signal. 7:ra72 (2014)　DOI: 10.1126/scisignal.2005199
  8. Tomiyama T, Ueda Y, Katakai T, Kondo N, Okazaki K, Kinashi T.　Antigen-specific suppression and immunological synapse formation by regulatory T cells require the mst1 kinase. PLoS One. 2013 Sep 9;8(9):e73874. doi: 10.1371/journal.pone.0073874
  9. Katakai T, Habiro K, Kinashi T. Dendritic Cells Regulate High-Speed Interstitial T Cell Migration in the Lymph Node via LFA-1/ICAM-1. J Immunol  191(3):1188-99.　2013  DOI: 10.4049/jimmunol.1300739
  10. Ueda Y., Katagiri K., Tomiyama T., Yasuda K., Habiro K., Katakai T., Ikehara S., Matsumoto M, Kinashi T.　Mst1 regulates integrin-dependent thymocyte trafficking and antigen-recognition in the thymus.　Nat. Commun. (2012) Oct 2;3:1098. doi: 10.1038/ncomms2105.　
  11. Katagiri, K., Ueda, Y., Tomiyama, T., Yasuda, K., Toda, Y., Ikehara, S., Nakayama, K.I., Kinashi, T. Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1.Immunity. 34;24-38. (2011)
  12. Ebisuno,Y.,Katagiri,K.,Katakai,T.,Ueda,Y.,Nemoto,T.,Inada,H.,Nakekura,J.,Okada,T.,
    Kannagi,R.,Tanaka,T.,Miyasaka,M.,Hogg,N.,Kinashi,T.　Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and-independent manners.Blood 28;115(4)804-814. (2010)
  13. 木梨達雄　リンパ節へのリンパ球のエントリーとmigrationのイメージング　医学のあゆみ　vol.231, No.13 1235-1240 (2010)
  14. Katagiri K,Katakai T,Ebisuno Y,Ueda Y,Okada T,Kinashi T. Mst1 controlslymphocyte trafficking and interstitial motility within lymph nodes.EMBO J. 6:26(9)1319-31. (2009)
  15. Katakai T, Suto H, Sugai M, Gonda H, Togawa A, Suematsu S, Ebisuno Y, Katagiri K, Kinashi T, Shimizu A. Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J Immunol. 1;181(9):6189-200. (2008)
  16. 木梨達雄　概論　細胞接着・移動の原理を探るー生体内環境が鍵を握る新局面　実験医学　vol.26,No.14 2168-2169 (2008 )
  17. 木梨達雄　Rap1-RAPLによるインテグリン制御とリンパ球動態　実験医学　vol.26,No.14 2174-2175 (2008 )
  18. 戎野幸彦、片桐晃子、木梨達雄　接着分子による免疫細胞動態調節と免疫応答　炎症と免疫　Vol.16、No.4　436－441（2008）
  19. Yoshikawa, Y., Satoh, T., Tamura, T., Wei, P., Bilasy, SE., Edamatsu, H., Aiba, A., Katagiri, K., Kinashi, T., Nakao, K., Kataoka, T. The M-Ras-RA-GEF-2Rap1 pathway mediates tumor-necrosis factor-alpha-dependent regulation of integrin activation in splenocytes. Mol.Biol.Cell, 18:2949-2959(2007)

  20. Kinashi, T. Integrin regulation of lymphocyte trafficking: Lessons from structural and signaling studies. Advances in immunology.93:185-227(2007)

  21. 木梨達雄　低分子量G蛋白質Rap1 によるインテグリンの制御　蛋白質核酸酵素　vol.52, No.12 1465-1471 (2007)

  22. Kinashi, T. Adhere upright: A switchblade-like extension of b2　integrins. Immunity. 25:521-522 (2006)

  23. Katagiri, K., Imamura, M. and Kinashi, T. Spatiotemporal regulation of the Kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nat. Immunol. 7:919-927 (2006)

  24. Kanemitsu,N., Ebisuno, Y., Tanaka, T., Otani, K., Hayasaka, H., Kaisho, T., Akira,S., Katagiri, K., Kinashi, T., Fujita, N., Tsuruo, T., Miyasaka, M. CXCL13 is an arrest chemokine for B cells in high endothelial venules. Blood. 106:2613-2618 (2005)

  25. Kinashi, T. and Katagiri, K. Regulation of immune cell adhesion and migration by regulator of adhesion and cell polarization enriched in lymphoid tissues.  Immunology  116: 164-171 (2005)

  26. Kinashi, T. Intracellular signaling controlling integrin activation in lymphocytes.  Nat. Rev. Immunol 5:546-559.(2005)

  27. 片桐晃子、木梨達雄　Rap1/RAPL 相互作用による血液系細胞の生態内動態制御　中山書店　免疫2006、岸本忠三編　42：92－98　（2005）

  28. Tamura T, Ariga H, Kinashi T, Uehara S, Kikuchi T, Nakada M, Tokunaga T, Xu W, Kariyone A, Saito T, Kitamura T, Maxwell G, Takaki S, Takatsu K. The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model.  Int Immunol. 16:1691-1699. (2004)

  29. Katagiri, K., Ohnishi, N.,  Kabashima, K., Iyoda, T., Takeda, N.,  Shinkai, Y.,  Inaba, K., andKinashi, T. Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat Immunol 5: 1045-1051 (2004).

  30. Noda, Y., Horikawa, S., Furukawa, T., Hirai, K., Katayama, Y., Asai, T., Kuwahara, M., Katagiri, K., Kinashi, T., Hattori, M., Minato, N. & Sasaki, S. Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1. FEBS Lett 568: 139-145 (2004).

  31. Kinashi, T. and Katagiri, K. Regulation of lymphocyte adhesion and migration by the small GTPase Rap1 and its effector molecule, RAPL. (review) Immunol. Lett.  93:1-5. (2004)

  32. Katagiri, K., Shimonaka, K. and Kinashi, T. Rap1-mediated LFA-1 activation by the T cell antigen receptor is dependent on PLC-g1. J. Biol. Chem.  279: 11875-11881. (2004)

  33. Kinashi, T., Aker, M., Sokolovsky-Eisenberg, M., Grabovsky, V., Tanaka, C., Shamri, R., Feigelson, S., Etzioni, A., and Alon, R.  LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds.  Blood 103: 1033-1036. (2004)

  34. 木梨達雄　Rap1エフェクター分子RAPLによる免疫細胞の動態制御　中山書店　　免疫2005、岸本忠三　120－126 (2004)

  35. Katagiri, K., Maeda, A., Shimonaka, M., and Kinashi, T. RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1.  Nat. Immunol.  4: 741-748. (2003)

  36. Tohyama, Y., Katagiri, K., Pardi, R., Lu, C., Springer, T. A., and Kinashi, T. The critical cytoplasmic regions of the aL/b2 integrin in Rap1-induced adhesion and migration.  Mol. Biol. Cell.  14: 2570-2582. (2003)

  37. Kabashima, K., Murata, T., Tanaka, H., Matsuoka, T., Sakata, D., Yoshida, N., Katagiri, K., Kinashi, T., Tanaka, T., Miyasaka, M., et al. Thromboxane A2 modulates interaction of dendric cells and T cells and regulates acquired immunity. Nat Immunol. 4:694-701. (2003).

  38. Shimonaka, M., K. Katagiri, T. Nakayama, N. Fujita, T. Tsuruo, O. Yoshie, and T. Kinashi.  Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow.  J. Cell Biol. 161: 417-427. (2003)