関西医科大学iPS・幹細胞再生医学講座

教室員

HOME教室員 > 薗田 精昭
客員教授
薗田 精昭
Yoshiaki Sonoda
学歴 昭和50年 京都府立医科大学医学部医学科卒
職歴
  • 昭和61年 米国南カロライナ医科大学実験血液学教室博士研究員
  • 昭和63年 京都府立医科大学講師(衛生学)
  • 平成 4年  京都府立医科大学助教授(衛生学)
  • 平成15年 京都府立医科大学大学院医学研究科助教授
         (分子標的癌予防医学)
  • 平成16年 関西医科大学衛生学講座主任教授
  • 平成17年 関西医科大学癌治療センター教授
  • 平成17年 関西医科大学大学院医学研究科先端医療学専攻
          修復医療応用系幹細胞生物学教授
  • 平成17年 関西医科大学再生医学難病治療センター教授
  • 平成19年 関西医科大学再生医学難病治療センター副センター長
  • 平成20年 関西医科大学専門部教務部長
  • 平成25年 関西医科大学附属生命医学研究所
          アイソトープ実験施設長
  • 平成30年 関西医科大学iPS・幹細胞再生医学講座客員教授
学位
(取得大学、年)
医学博士(京都府立医科大学、昭和59年)
資格 医師、日本内科学会認定専門医、日本血液学会認定専門医、
日本血液学会認定血液指導医、産業医
E-mail sonoda@hirakata.kmu.ac.jp
研究テーマ 幹細胞生物学、再生医学・医療、幹細胞移植学、血液学、
環境生命医学
研究のキーワード 造血幹細胞、組織幹細胞、造血幹細胞移植、再生医療、がん幹細胞
主要業績
  • Sumide K, Matsuoka Y, Kawamura H, Nakatsuka R, Fujioka T, Asano H, Takihara Y and Sonoda Y, A Rivised Road Map for the Comittment of Human Cord Blood CD34-negative Hematopoietic Stem Cells, Nature Communications, in press
  • Kawamura H, Nakatsuka R, Matsuoka Y, Sumide K, Fujioka T, Asano H, Iida H and Sonoda Y, TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells, Stem Cell Reports, 10(3):920-32,2018
  • Matsuoka Y, Takahashi M, Sumide K, Kawamura H, Nakatsuka R, Fujioka T, Sonoda Y: CD34 Antigen and the MPL Receptor Expression Defines A Novel Class Of Human Cord Blood-Derived Primitive Hematopoietic Stem Cells. Cell Transplant 26(6):1043-1058,2017.
  • Sonoda Y: Human Hematopoietic Stem Cells: The Current Understanding and Future Prospects. Journal of Hematopoietic Cell Transplantation 6(2):70-83,2017.
  • Matsuoka Y, Sumide K, Kawamura H, Nakatsuka R, Fujioka T, Sonoda Y: GPI-80 expression highly purifies human cord blood-derived primitive CD34-negative hematopoietic stem cells. Blood 128(18):2258-2260, 2016.
  • Nakatsuka R, Iwaki R, Matsuoka Y, Sumide K, Kawamura H, Fujioka T, Sasaki Y, Uemura Y, Asano H, Kwon A-Hon, Sonoda Y: Identification and Characterization of Lineage-CD45-Sca-1+ VSEL Phenotypic Cells Residing in Adult Mouse Bone Tissue. Stem Cells Dev 25(1):27-42,2016.
  • Zhang R, Liu T-Y, Senju S, Haruta M, Hirosawa N, Suzuki M, Tatsumi M, Ueda N, Maki H, Nakatsuka R, Matsuoka Y, Sasaki Y, Tsuzuki S, Nakanishi H, Araki R, Abe M, Akatsuka Y, Sakamoto Y, Sonoda Y, Nishimura Y, Kuzushima K, Uemura Y: Generation of mouse pluripotent stem cell-derived proliferating myeloid cells as an unlimited source of functional antigen-presenting cells. Cancer Immunol Res, 3(6):668-677, 2015.
  • Matsuoka Y, Nakatsuka R, Sumide K, Kawamura H, Takahashi M, Fujioka T, Uemura Y, Asano H, Sasaki Y, Inoue M, Ogawa H, Takahashi T, Hino M, Sonoda Y: Prospectively isolated human bone marrow cell-derived MSCs support primitive human CD34-negative hematopoietic stem cells. Stem Cells 33:1554-1565, 2015.
  • Matsuoka Y, Sumide K, Kawamura H, Nakatsuka R, Fujioka T, Sasaki Y, Sonoda Y: Human cord blood-derived CD34-negative hematopoietic stem cells (HSCs) are myeloid-biased long-term repopulating HSCs. Blood Cance J , 5:e290;doi:10.1038/bcj. 2015.
  • Nakatsuka R, Matsuoka Y, Uemura Y, Sumide K., Iwaki R, Takahashi M, Fujioka T, Sasaki Y, Sonoda Y. Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/progenitor cells in vitro. Cell Transplant, 24:97-113, 2015.
  • Sonoda Y: Human CD34-negative hematopoietic stem cells. Book chapter in Ratajczak M, ed. “Adult Stem Cell Therapies : Alternatives to Plasticity”. Humana Press, Springer, Berlin, pp.53-77, 2014.
  • Takahashi M, Matsuoka Y, Sumide K, Nakatsuka R, FujiokaT, Kohno H, Sasaki Y, Matsui K, Asano H, Kaneko K, Sonoda Y. CD133 is a Positive Marker for a Distinct Class of Primitive Human Cord Blood-derived CD34?negative Hematopoietic Stem Cells. Leukemia,28:1308-1315, 2014.
  • Ishii M, Matsuoka Y, Sasaki Y, Nakatsuka R, Takahashi M, Nakamoto T, Yasuda K, Matsui K, Asano H, Uemura Y, Tsuji T, Fukuhara S, Sonoda Y. Development of a high-resolution purification method for precise functional characterization of primitive human cord blood-derived CD34-negative SCID-repopulating cells. Exp Hematol 39:203-213 2011.
  • Matsuoka Y, Sasaki Y, Nakatsuka R, Takahashi M, Iwaki R, Uemura Y, Sonoda Y. The low level of c-kit expression marks deeply quiescent murine hematopoietic stem cells. Stem Cells 29:1783-1791,2011.
  • Kimura T, Kohno H, Matsuoka Y, Murakami M, Nakatsuka R, Hase H, Yasuda K, Uemura Y, Sasaki Y, Fukuhara S, Sonoda Y. CXCL8 enhances the angiogenic activity of umbilical cord blood-derived outgrowth endothelial cells in vitro. Cell Biol Int 35:201-208,2011.
  • Kimura T, Kohno H, Matsuoka Y, Nakatsuka R, Sasaki Y, Fukuhara S, Sonoda Y. CD16 antigen is a positive marker of peripheral blood-derived early endothelial progenitor cells. Int J Hematol 93:123-125,2011.
  • Nakatsuka R, Nozaki T, Uemura Y, Matsuoka Y, Sasaki Y, Shinohara M, Ohura K, Sonoda Y. 5-Aza-2’-deoxycytidine treatment induces skeletal myogenic differentiation of mouse dental pulp stem cells. Arch Oral Biol 55:350-357, 2010
  • Kimura T, Matsuoka Y, Murakami M, Kimura T, Takahashi M, Nakamoto T, Yasuda K, Matsui K, Kobayashi K, Imai S, Asano H, Nakatsuka R, Uemura Y, Sasaki Y, Sonoda Y. In vivo dynamics of human cord blood-derived CD34- SCID-repopulating cells using intra-bone marrow injection. Leukemia 24:162-168,2010.
  • Sasaki Y, Matsuoka Y, Hase M, Toyohara T, Murakami M, Takahashi M, Nakatsuka R, Uemura Y, Sonoda Y. Marginal expression of CXCR4 on c-kit+Sca-1+Lineage- hematopoietic stem/progenitor cells. Int J Hematol 90:553-560,2009.
  • Sonoda Y. Immunophenotype and functional characteristics of human primitive CD34-negative hematopoietic stem cells: The significance of the intra-bone marrow injection. J Autoimmun 30:136-144, 2008.
  • Kimura T, Asada R, Wang J, Kimura T, Morioka M, Matsui K, Kobayashi K, Henmi K, Imai S, Kita M, Tsuiji T, Sasaki Y, Ikehara S, Sonoda Y. Identification of long-term repopulating potential of human cord blood-derived CD34-flt3- severe combined immunodeficiency- repopulating cells by intra-bone marrow injection. Stem Cells 25:1348-1355, 2007.
  • Kimura T, Wang J, Matsui K, Imai S, Yokoyama S, Nishikawa M, Ikehara S, Sonoda Y. Proliferative and migratory potentials of human cord blood-derived CD34- severe combined immunodeficiency repopulating cells that retain secondary reconstituting capacity. Int J Hematol79:328-333,2004.
  • Kimura T, Minamiguchi H, Wang J, Kaneko H, Nakagawa H, Fujii H, Sonoda Y. Impaired stem cell functions of CD34+ cells selected by two different immunomagnetic beads systems. Leukemia 18:566-574,2004.
  • Wang J, Kimura T, Asada R, Harada S, Yokota S, Kawamoto Y, Fujimura Y, Tsuji T, Ikehara S, Sonoda Y. SCID-repopulating cell activity of human cord blood-derived CD34- cells assured by intra-bone marrow injection. Blood 101:2924-2931,2003. (Plenary paper)
  • Fujiki H, Kimura T, Minamiguchi H, Harada S, Wang J, Nakao M, Yokota S, Urata Y, Ueda Y, Yamagishi H, Sonoda Y. Role of human interleukin-9 as a megakaryocyte potentiator in culture. Exp Hematol 30:1373-1380,2002.
  • Minamiguchi H, Kimura T, Urata Y, Miyazaki H, Bamba T, Abe T, Sonoda Y. Simultaneous signaling through c-mpl, c-kit, and CXCR4 enhances the proliferation and differentiation of human megakaryocyte progenitors: possible roles of the PI3-K, PKC, and MAPK pathways. Br J Haematol 115:175-185, 2001.
  • Minamiguchi H, Yahata N, Kimura T, Fujiki H, Harada S, Wang J, Okuda K, Kaneko H, Hodohara K, Banba T, Yasukawa K, Ohyashiki JH, Ohyashiki K, Abe T, Sonoda Y. Interleukin 6 receptor expression by human cord blood- or peripheral blood-derived primitive haematopoietic progenitors implies acquisition of different functional properties. Br J Haematol 110:327-338,2000.
  • Kimura T, Wang J, Minamiguchi H, Fijiki H, Harada S, Okuda K, Kaneko H, Yokota S, Yasukawa K, Abe T, Sonoda Y. Signal through gp130 activated by soluble interleukin(IL)-6 receptor(R) and IL-6 or IL-6R/IL-6 fusion protein enhances ex vivo expansion of human peripheral blood-derived hematopoietic progenitors. Stem Cells 18:444-452,2000.
  • Kimura T, Sakabe H, Minamiguchi H, Fujiki H, Abe T, Kaneko H, Yokota S, Nakagawa H, Fujii H, Tamaki H, Ogawa H, Sugiyama H, Sonoda Y. Inteleukin-11(IL-11) enhances clonal proliferation of acute myelogenous leukemia cells with strong expression of the IL-11 receptor α and signal transducing gp130. Leukemia 13:1018-1027,1999.
  • Sakabe H, Kimura T, Zeng Z, Minamiguchi H, Tsuda S, Yokota S, Hodohara K, Abe T, Lyman SD, Sonoda Y. Haematopoietic action of flt3 ligand on cord blood-derived CD34-positive cells expressing different levels of flt3 or c-kit tyrosine kinase receptor: comparison with stem cell factor. Eur J Haematol 60: 297-306, 1998.
  • Sakabe H, Yahata N, Kimura T, Zeng ZZ, Minamiguchi H, Kaneko H, Mori KJ, Ohyashiki K, Ohyashiki JH, Toyama K, Abe T, Sonoda Y. Human cord blood-derived primitive progenitors are enriched in CD34+c-kit- cells: correlation between long-term culture-initiating cells and telomerase expression. Leukemia 12:728-734,1998.
  • Sakabe H, Ohmizono Y, Tanimukai S, Kimura T, Mori KJ, Abe T, Sonoda Y. Functional differences between subpopulations of mobilized peripheral blood-derived CD34+ cells expressing different levels of HLA-DR, CD33, CD38, and c-kit antigens. Stem Cells 15:73-81,1997.
  • Sonoda Y, Kimura T, Ohmizono Y, Sakabe H, Tanimukai S, Yokota S, Clark SC, Abe T.: Action of human interleukin-4 and stem cell factor on erythroid and mixed colony formation by peripheral blood-derived CD34+c-kithigh or CD34+c-kitlow cells. Br J Haematol 96:781-789, 1997.
  • Ohmizono Y, Sakabe H, Kimura T, Tanimukai S, Matsumura T, Miyazaki H, Lyman SD, Sonoda Y. Thrombopoietin augments ex vivo expansion of human cord blood-derived hematopoietic progenitors in combination with stem cell factor and flt3 ligand. Leukemia 11: 524-530, 1997.
  • Sonoda Y, Kimura T, Sakabe H, Tanimukai S, Ohmizono Y, Nakagawa S, Yokota S, Lyman SD, Abe T. Human flt3 ligand acts on myeloid as well as multipotential progenitors derived from purified CD34+ blood progenitors expressing different levels of c-kit protein. Eur J Haematol 58: 257-264,1997.
  • Tanimukai S, Kimura T, Sakabe H, Ohmizono Y, Kato T, Miyazaki H, Yamagishi H, Sonoda Y. Recombinant human c-Mpl ligand(thrombopoietin) not only acts on megakaryocyte progenitors, but also on erythroid and multipotential progenitors in vitro. Exp Hematol 25:1025-1033,1997.
  • Kimura T, Sakabe H, Tanimukai S, Abe T, Urata Y, Yasukawa K, Okano A, Taga T, Sugiyama H, Kishimoto T, Sonoda Y. Simultaneous activation of signals through gp130, c-kit, and interleukin-3 receptor promotes a trilimeage blood cell production in the absence of terminally acting lineage-specific factors. Blood 90:4767-4778, 1997.
  • Ariyama Y, Misawa S, Sonoda Y. Synergistic effects of stem cell factor and interleukin 6 or interleukin 11 on the expansion of murine hematopoietic progenitors in liquid suspension culture. Stem Cells 13: 404-413, 1995.
  • Sonoda Y, Sakabe H, Ohmisono Y, Tanimukai S, Yokota S, Nakagawa S, Clark SC, Abe T. Synergistic actions of stem cell factor and other burst-promoting activities on proliferation of CD34+ highly purified blood progenitors expressing HLA-DR or different levels of c-kit protein. Blood 84:4099-4106,1994.
  • Sonoda Y, Kuzuyama Y, Tanaka S, Yokota S, Maekawa T, Clark SC, Abe T.: Human interleukin-4 inhibits proliferation of megakaryocyte progenitor cells in culture. Blood 81:624-630,1993.
  • Sonoda Y, Okuda T, Yokota S, Maekawa T, Shizumi Y, Nishigaki N, Misawa S, Fujii H, Abe T. Actions of human interleukin-4/B-cell stimulatory factor-1 on proliferation and differentiation of enriched hematopoietic progenitor cells in culture. Blood 75:1615-1621,1990.
  • Sonoda Y, Arai N, Ogawa M. Humoral regulation of eosinophilopoiesis in vitro: Analysis of the targets of interleukin-3, granulocyte/macrophage colony- stimulating factor (GM-CSF) and interleukin-5. Leukemia 3:14-18, 1989.
  • Sonoda Y, Ogawa M. Serum-free culture of human hemopoietic progenitors in attenuated culture media. Am. J. Hematol 28:227-231,1988.
  • Sonoda Y, Yang Y-C, Wong GG, Clark SC, Ogawa M. Erythroid burst-promoting activity of purified recombinant human GM-CSF and Interleukin-3:Studies with anti-GM-CSF and anti-IL-3 sera and studies in serum-free cultures. Blood 72: 1381-1386,1988.
  • Sonoda Y, Yang Y-C, Wong GG, Clark SC, Ogawa M.: Analysis in serum-free culture of the targets of recombinant human hemopoietic factors:Demonstration that interleukin-3 and granulocyte/ macrophage colony-stimulating factors are specific for early developmental stages. Proc Natl Acad Sci USA 85:4360-4364,1988.
加入学会・役職等
  • 日本血液学会
    (代議員、2004~2006プログラム委員、2008~2010プログラム委員、2009~2011 IJH Editorial Board Member)
  • 日本造血細胞移植学会
    (理事、評議員、在り方委員会委員、臨床研究委員会委員、倫理審査委員会委員長、理事評議員選任委員会委員長)
  • 日本サイトメトリー学会
    (理事長、編集委員会委員長、在り方委員会委員)
  • 日本再生医療学会(評議員)
  • 日本衛生学会(評議員)
  • 近畿臍帯血幹細胞移植研究会(世話人)
  • 京都造血幹細胞移植研究会(幹事)
  • アメリカ血液学会 (ASH)会員
  • 国際実験血液学会 (ISEH)会員
  • 国際幹細胞学会(ISSCR)会員
  •  
  • その他
  • 日本赤十字社近畿さい帯血バンク(適応判定委員会委員)
  • 京都府立医科大学雑誌編集委員(1996年~2004年)
  • Editorial Board Member of Haematologica (Journal of Hematology) (1999年~2000年)
  • Cytometry Research誌編集委員(2005年~2011年)
  • Cytometry Research誌編集委員長(2011年~)
  • Editorial Board Member of International Journal of Hematology (2009年~2011年)
  • 第21回日本サイトメトリー学会学術集会会長(平成23年6月)
  • 第34回日本造血細胞移植学会学術集会会長(平成24年2月)
  • 第21回近畿臍帯血幹細胞移植研究会当番世話人(平成25年5月)
更新日 2018年6月1日

教室員一覧へ