原著論文    Original Articles

Nadya NA, Tezuka H, Ohteki T, Matsuda S., Azuma M, and *Nagai S.
PI3K-Akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells.
Immunology. (2017) 152: 507-516

Arima, M., Cui, D., Kimura, T., Sonoda, K.H., Ishibashi, T., Matsuda, S., and Ikeda, E.
Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy.
Sci. Rep. (2016) 6: 38445. (doi: 10.1038/srep38445.)

Cui, D., Arima, M., Takubo, K., Kimura, T., Horiuchi, K., Minagawa, T., Matsuda, S., and Ikeda, E.
ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function.
Sci. Rep. (2015) 5: 12796. (doi: 10.1038/srep12796.)

Hoshii, T., Kasada, A., Hatakeyama, T., Ohtani, M., Tadokoro, Y., Naka, K., Ikenoue, T., Ikawa, T., Kawamoto, H., Fehling, H.J., Araki, K., Yamamura, K., Matsuda, S., and Hirao, A.
Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.
Proc. Natl. Acad. Sci. USA. (2014) 111(10): 3805-3810.

Hirata, Y., Sugie, A., Matsuda, A., Matsuda, S., and Koyasu, S.
TAK1-JNK axis mediates survival signal through Mcl1 stabilization in activated T cells.
J. Immunol. (2013) 190(9): 4621-4626.

Takayama, G., Ohtani, M., Minowa, A., Matsuda, S., and Koyasu, S.
Class I PI3K-mediated Akt and ERK signals play a critical role in FcεRI-induced degranulation in mast cells.
Int. Immunol. (2013) 25(4): 215-220.

Powers, S. E., Mandal,M., Matsuda, S., Miletic, A. V., Cato, M. C., Tanaka, A., Rickert, R. C., Koyasu, S., and Clark, M. R.
Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression.
J. Exp. Med. (2012) 209: 2199-2213.

Ohtani, M., Hoshii, T., Fujii, H., Koyasu, S., Hirao, A. and Matsuda, S.
mTORC1 in intestinal CD11c+CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production
J.Immunol. (2012) 188: 4736-4740.

Kurebayashi, Y., Nagai, S., Ikejiri, A., Ohtani, M., Ichiyama, K., Baba, Y., Yamada, T., Egami, S., Hoshii, T., Hirao, A., Matsuda, S., and Koyasu, S.
PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi-1 expression and nuclear translocation of RORγ
Cell Reports (2012) 1: 360-373.

Yokoyama, T., Matsuda, S., Takae, Y., Wada, N., Nishikawa, T., Amagai, M., and Koyasu, S.
Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris.
Int. Immunol. (2011) 23: 365-373.

Moro, K., Yamada, T., Tanabe, M., Takeuchi, T., Ikawa, T., Kawamoto, H., Furusawa, JI., Ohtani, M., Fujii, H., and Koyasu, S.
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells.
Nature (2010) 463: 540-544.

Matsuda, S., Mikami, Y., Ohtani, M., Fujiwara, M., Hirata, Y., Minowa, A., Terauchi, Y., Kadowaki, T., and Koyasu, S.
Critical role of class IA PI3K for c-Rel expression in B lymphocytes.
Blood (2009) 113: 1037-1044.

Ohtani, M., Nagai, S., Kondo, S., Mizuno, S., Nakamura, K., Tanabe, M., Takeuchi, T., Matsuda, S., and Koyasu, S.
mTOR and GSK3 differentially regulate LPS-induced IL-12 production in dendritic cells.
Blood (2008)112:635-643.

Fujii, Y., Matsuda, S., Takayama, G., and Koyasu, S.
ERK5 is involved in TCR-induced apoptosis through the modification of Nur77.
Genes Cells (2008)13: 411-419.

Shiroki, F., Matsuda, S., Doi, T., Fujiwara, M., Mochizuki, Y., Kadowaki, T., Suzuki, H., and Koyasu, S.
The p85α regulatory subunit of class IA phosphoinositide 3-kinase regulates β-selection in thymocyte development.
J. Immunol. (2007) 178: 1349-1356.

Murayama, T., Tanabe, M., Matsuda, S., Shimazu, M., Kamei, S., Wakabayashi, G., Kawachi, S., Matsumoto, K., Yamazaki, K., Matsumoto, K., Koyasu, S., and Kitajima, M.
JNK (c-Jun NH2 terminal kinase) and p38 during ischemia reperfusion injury in the small intestine.
Transplantation. (2006) 81: 1325-1330.

Matsuda, S., Miwa, Y., Hirata, Y., Minowa, A., Tanaka, J., Nishida, E., and Koyasu, S.
Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT.
EMBO J.(2004) 23: 2577-2585.

Nakaoka, Y., Nishida, K., Fujio, Y., Izumi, M., Terai, K., Oshima, Y., Sugiyama, S., Matsuda, S., Koyasu, S., Yamauchi-Takihara, K., Hirano, T., Kawase, I., Hirota, H.
Activation of gp130 Transduces Hypertrophic Signal Through Interaction of Scaffolding/Docking Protein Gab1 With Tyrosine Phosphatase SHP2 in Cardiomyocytes.
Circ. Res. (2003) 93: 221-229.

*Suzuki, H., *Matsuda, S., Terauchi, Y., Fujiwara, M., Ohteki, T., Asano, T., Behrens, T. W., Kouro, T., Takatsu, K., Kadowaki, T., and Koyasu, S.
PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction.
Nat. Immunol. (2003) 4: 280-286. (*equally contributed)

Fukao, T., Tanabe, M., Terauchi, Y., Ota, T., Matsuda, S., Asano, T., Kadowaki, T., Takeuchi, T. and Koyasu. S.
PI3K-mediated negative feedback regulation of IL-12 production in dendritic cells.
Nat. Immunol. (2002) 3: 875-881.

Sano, M., Fukuda, K., Sato, T., Kawaguchi, H., Suematsu, M., Matsuda, S., Koyasu, S., Matsui, H., Yamaguchi-Takihara, K., Harada, M., Saito, Y., and Ogawa, S.
ERK and p38 MAPK, but not NF-κB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts.
Circ. Res. (2001) 89: 661-669.

Matsuda, S., Shibasaki, F., Takehana, K., Mori, H., Nishida, E., and Koyasu, S.
Two distinct action mechanisms of immunophiline-ligand complexes for the blockade of T cell activation.
EMBO Rep. (2000) 1: 428-434.

Tsuchihashi, N., Matsuda, S., Reinherz, E. L., and Koyasu, S.
Two YxxL segements of a single ITAM in the CD3ε molecule differentially activate calcium mobilization and MAPK family pathways.
Eur. J. Immunol. (2000) 30: 1785-1793.

Ueno, H., Matsuda, S., Katamura, K., Mayumi, M., and Koyasu, S.
ZAP-70 is required for calcium mobilization but is dispensable for MAPK superfamily activation induced via CD2 in human T cells.
Eur. J. Immunol. (2000) 30: 78-86.

Fukao, T., Matsuda, S., and Koyasu, S.
Synergistic effects of interleukin (IL)-4 and IL-18 on IL-12 dependent interferon-γ production by dendritic cells.
J. Immunol. (2000) 164: 64-71.

Matsuda, S., Suzuki-Fujimoto, T., Minowa, A., Ueno, H., Katamura, K., and Koyasu, S.
Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway: restoration of a kinase domain mutant by Cdc37.
J. Biol. Chem. (1999) 274: 34515-34518.

Matsuda, S., Minowa, A., Suzuki, S., and Koyasu, S.
Differential activation of c-Jun NH2 terminal kinase and p38 pathways during FTY720 induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway.
J. Immunol. (1999) 162: 3321-3326.

Katamura, K., Tai, G., Tachibana, T., Yamabe, H., Ohmori, K., Mayumi, M., Matsuda, S., Koyasu, S., and Furusho, K.
Existence of activated and memory CD4+ T cells in peripheral blood and their skin infiltration in CD8 deficiency.
Clin. Exp. Immunol.(1999) 115: 124-130.

Matsuda, S., Moriguchi, T., Koyasu, S., and Nishida, E.
T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A.
J. Biol. Chem. (1998) 273: 12378-12382.

Shirakabe, K., Yamaguchi, K., Shibuya, H., Irie, K., Matsuda, S., Moriguchi, T., Gotoh, Y., Matsumoto, K., and Nishida, E.
TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase.
J. Biol. Chem. (1997) 272: 8141-8144.

Kamata, H., Tanaka, C., Yagisawa, H., Matsuda, S., Gotoh, Y., Nishida, E., and Hirata, H.
Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade.
J. Biol. Chem. (1996) 271: 33018-33025.

Kawasaki, H., Moriguchi, T., Matsuda, S., Li, H. Z., Nakamura, S., Shimohama, S., Kimura, J., Gotoh, Y., and Nishida, E.
Ras-dependent and Ras-independent activation pathways for the stress-activated-protein-kinase cascade.
Eur. J. Biochem. (1996) 241: 315-321.

Moriguchi, T., Kawasaki, H., Matsuda, S., Gotoh, Y., and Nishida, E.
Evidence for multiple activators for stress-activated protein kinase/c-Jun amino-terminal kinases. Existence of novel activators.
J. Biol. Chem. (1995) 270: 12969-12972.

Matsuda, S., Kawasaki, H., Moriguchi, T., Gotoh, Y., and Nishida, E.
Activation of protein kinase cascades by osmotic shock.
J. Biol. Chem. (1995) 270: 12781-12786. Gotoh, Y., Matsuda, S., Takenaka, K., Hattori, S., Iwamatsu, A., Ishikawa, M., Kosako, H., and Nishida, E.
Characterization of recombinant Xenopus MAP kinase kinases mutated at potential phosphorylation sites.
Oncogene. (1994) 9: 1891-1898.

Ueki, K., Matsuda, S., Tobe, K., Gotoh, Y., Tamemoto, H., Yachi, M., Akanuma, Y., Yazaki, Y.,Nishida, E., and Kadowaki, T.
Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation.
J. Biol. Chem. (1994) 269: 15756-15761.

Matsuda, S., Gotoh, Y., and Nishida, E.
Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.
J. Biol. Chem. 268: 3277-3281.

Tobe, K., Kadowaki, T., Hara, K., Gotoh, Y., Kosako, H., Matsuda, S., Tamemoto, H., Ueki, K., Akanuma, Y., Nishida, E., et al.
Sequential activation of MAP kinase activator, MAP kinases, and S6 peptide kinase in intact rat liver following insulin injection.
J. Biol. Chem. (1992) 267: 21089-21097.

Kosako, H., Gotoh, Y., Matsuda, S., Ishikawa, M., and Nishida, E.
Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.
EMBO J. (1992) 11: 2903-2908.

Matsuda, S., Kosako, H., Takenaka, K., Moriyama, K., Sakai, H., Akiyama, T., Gotoh, Y., Nishida, E.
Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.
EMBO J. (1992) 11: 973-982.

Gotoh, Y., Moriyama, K., Matsuda, S., Okumura, E., Kishimoto, T., Kawasaki, H., Suzuki, K., Yahara, I., Sakai, H., and Nishida, E.
Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.
EMBO J. (1991) 10: 2661-2668.

Gotoh, Y., Nishida, E., Matsuda, S., Shiina, N., Kosako, H., Shiokawa, K., Akiyama, T., Ohta, K., Sakai, H.
In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase.
Nature. (1991) 349: 251-254.

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