業績publication

2018

▶ Hara H, Takeda N, zSaito T, Fujiwara T, Maemura S, Hata Y, Uchiyama M, and Komuro I. (2017) "Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury" JACC: Basic to Translational Science Circulation. 2017;136:A13763

2017

▶ Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Ishigaki K, Saiga K, Ohsugi H, Tokuyama Y, Imahashi Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M, and Ueno H. (2017) "Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity" Scientific Reports doi:10.1038/s41598-017-09927-2

▶ Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, DaviesPS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, and Kuo CJ. (2017) "Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem cell self-renewal" Nature doi:10.1038/nature22313

▶ Jinshu Xu, Ueno H,Chelsea Xu, Binglai Chen, Irving Weissman, and Pin-Xian Xu. (2017) "Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti" Nature Communications doi:10.1038/ncomms15046

▶ Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Ishigaki K, Saiga K, Ohsugi H, Tokuyama Y, Imahashi Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M and Ueno H. (2017) "Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion" Scientific Reports doi:10.1038/srep41838

2016

▶ Tanaka T, Atsumi N, Nakamura N, Yanai H, Komai Y, Omachi T, Tanaka K, Ishigaki K, Saiga K, Ohsugi H, Tokuyama Y, Imahashi Y, Hisha H, Yoshida N, Kumano K, Okazaki K, and Ueno H. (2016) "Bmi1-positive cells in the lingual epithelium could serve as cancer stem cells in tongue cancer" Scientific Reports doi:10.1038/srep39386

▶ Hisha H,and Ueno H. (2016) "Organoid Culture of Lingual Epithelial Cells in a Three-Dimensional Matrix." Methods in molecular biology :Aug19[Epub ahead of print]

Ueno H. (2016) "Identification of normal and neoplastic stem cells by the multicolor lineage tracing methods."
Pathology International doi:10.1111/pin.12425

▶ Hisha H, Tanaka T and Ueno H. (2016) "Lingual Epithelial Stem Cells and Organoid Culture of Them" International Journal of Molecular Sciences doi:10.3390/ijms17020168

2015

▶ Ohe S, Tanaka T, Yanai H, Komai Y, Omachi T, Kanno S, Tanaka K, Ishigaki K, Saiga K, Nakamura N, Ohsugi H, Tokuyama Y, Atsumi N, Hisha H, Yoshida N, Kumano K, Yamazaki F, Okamoto H, Ueno H. (2015) "Maintenance of sweat glands by stem cells located in the acral epithelium" Biochem Biophys Res Commun doi:10.1016/j.bbrc.2015.09.022

▶ Tanaka K, Kumano K, and Ueno H. (2015) "Intracellular signals of lung cancer cells as possible therapeutic targets" Cancer Science doi: 10.1111/cas.12643

2014

▶ Komai Y, Tanaka T, Tokuyama Y, Yanai H, Ohe S, Omachi T, Atsumi N, Yoshida N, Kumano K, Hisha H, Matsuda T, and Ueno H. (2014) "Bmi1 expression in long-term germ stem cells" Scientific Reports DOI:10.1038/srep06175


2013

▶ Hisha H, Tanaka T, Kanno S, Tokuyama Y, Komai Y, Ohe S, Yanai H, Omachi T, and Ueno H. (2013) "Establishment of a Novel Lingual Organoid Culture System: Generation of Organoids Having Mature Keratinized Epithelium from Adult Epithelial Stem Cells."
Scientific Reports 3, Article number:3224|doi:10.1038/srep03224


▶ Tanaka T, Komai Y, Tokuyama Y, Yanai H, Ohe H, Okazaki K, and Ueno H. (2013) "Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells." Nature Cell Biology;15:511-518 (2013) doi:10.1038/ncb2719
2013


▶ Yanai H, Tanaka T, Ueno H. (2013) "Multicolor lineage tracing methods and intestinal tumors" Journal of Gastroenterology 4:423-433
2013


2012

▶ Zhang H, Zheng W, Shen Y, Adhikari D, Ueno H (co-corresponding author), Liu K. (2012) Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries Proc Natl Acad Sci USA 109:12580-12585
2012


2011

▶ Rinkevich Y, Lindau P, Ueno H, Longaker M, Weissman IL, Germ layer and lineage restricted stem/progenitors regenerate the mouse digit tip. (2011) Nature 476:409-413
2011


2010

▶ Red-Horse K, Ueno H, Weissman IL, Krasnow MA. (2010) Coronary arteries form by developmental reprogramming of differentiated venous cells. Nature;464:549-53
2011

Ueno H, and Weissman IL. (2010) The Origin and Fate of Yolk Sac Hematopoiesis: Application of Chimera Analyses to Developmental Studies. Int J Dev Biol (special issue, Developmental Hematology) 54, 1019-1031
2010-2


2009

▶ Ootani A, Li X, Sangiorgi E, Ho Q, Ueno H, Toda S, Sugihara H, Fujimoto K, Weissman IL, Capecchi MR, and Kuo C. (2009) Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat Med, 15, 701-706.
2009

Ueno H, Turnbull BB, and Weissman IL. (2009) Two-step oligoclonal development of male germ cells. Proc Natl Acad Sci USA, 106, 175-180
2009-2

2008

▶ Voskoboynik A, Soen Y, Rinkevich Y, Rosner A,Ueno H, Reshef R, Ishizuka KJ, Palmeri KJ, Moiseeva E, Rinkevich B, and Weissman IL. (2008) Identification of the Endostyle as a Stem Cell Niche in a Colonial Chordate. Cell Stem Cell, 3, 456-464
2008

▶ Komori T, Gyobu H, Ueno H, Kitamura T, Senba E, Morikawa Y. (2008) Expression of kin of irregular chiasm-like 3/mKirre in propriocetive neurons of the dorsal root ganglia and its interaction with nephrin in muscle spindles. J Comp Neurol, 511, 92-108
2008-2

▶ Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida K, Naito A, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Asashima M, Komuro I. (2008) IGFBP-4 is an inhibitor of canonical Wnt signaling required for cardiogenesis. Nature, 454, 345-349
2008-3

▶ Beliakoff J, Lee J, Ueno H, Aiyer A, Weissman I L, Barsh G S, Cardiff R D, and Sun Z. (2008). The PIAS-like Protein Zimp10 is Essential for Embryonic Viability and Proper Vascular Development. Mol Cell Biol. 28, 282-292
2008-4



2007

Ueno H, and Weissman I L. (2007) Stem cells: blood lines from embryo to adult. Nature (News & Views) 446 , 996-997.
2007

▶ Morikawa Y, Komori T, Hisaoka T, Ueno H, Kitamura T, and Senba E. (2007). Expression of mKirre in the developing sensory pathways: Its close apposition to nephrin-expressing cells. Neuroscience. 150, 880-886
2007-2



2006

Ueno H, and Weissman I L. (2006). Clonal analysis of mouse development reveals a polyclonal origin for yolk sac blood islands. Dev Cell 11 , 519-533.
2006



2005

▶ Tamura S, Morikawa Y, Hisaoka T, Ueno H, Kitamura T, and Senba E. (2005). Expression of mKirre, a mammalian homolog of Drosophila kirre, in the developing and adult mouse brain. Neuroscience 133 , 615-624.
2005



2004

▶ Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S. (2004). Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Hum Mol Genet 13 , 171-179.
2004



2003

Ueno H, Sakita-Ishikawa M, Morikawa Y, Nakano T, Kitamura T, and Saito M. (2003). A stromal cell-derived membrane protein that supports hematopoietic stem cells. Nat Immunol 4 , 457-463.
2003



2000

▶ Nakamoto T, Yamagata T, Sakai R, Ogawa S, Honda H, Ueno H, Hirano N, Yazaki Y, and Hirai H. (2000). CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases. Mol Cell Biol 20 , 1649-1658.
2000

Ueno H, Kondo E, Yamamoto-Honda R, Tobe K, Nakamoto T, Sasaki K, Mitani K, Furusaka A, Tanaka T, Tsujimoto Y, Hirai H. (2000) Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function. Mol Biol Cell 11, 735-746.
2000-2



1999

▶ Honda H, Harada K, Komuro I, Terasaki F, Ueno H, Tanaka Y, Kawamura K, Yazaki Y, and Hirai H. (1999) Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice. Oncogene 18 , 3821-3830.



1998

Ueno H, and Odai H. (1998) [Constitutive activation of B cell antigen receptor-associated tyrosine kinases in B cell leukemia/lymphoma lines]. Rinsho Ketsueki - Japanese Journal of Clinical Hematology. 39 , 89-91.

Ueno H, Sasaki K, Honda H, Nakamoto T, Yamagata T, Miyagawa K, Mitani K, Yazaki Y, and Hirai H. (1998) c-Cbl is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3'-kinase pathway. Blood 91 , 46-53.
1998



1997

▶ Nakamoto T, Sakai R, Honda H, Ogawa S, Ueno H, Suzuki T, Aizawa S, Yazaki Y, and Hirai H. (1997) Requirements for localization of p130cas to focal adhesions. Mol Cell Biol 17 , 3884-3897.
1997

▶ Odai H, Sasaki K, Iwamatsu A, Nakamoto T, Ueno H, Yamagata T, Mitani K, Yazaki Y, and Hirai H. (1997). Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl. Blood 89 , 2745-2756.
1997-2

Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, and Hirai H. (1997) The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase. Oncogene 14 , 3067-3072.

Ueno H, Sasaki K, Miyagawa K, Honda H, Mitani K, Yazaki Y, and Hirai H. (1997) Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling. J Biol Chem 272 , 8739-8743.

▶ Yamagata T, Mitani K, Ueno H, Kanda Y, Yazaki Y, and Hirai H. (1997) Triple synergism of human T-lymphotropic virus type 1-encoded tax, GATA-binding protein, and AP-1 is required for constitutive expression of the interleukin-5 gene in adult T-cell leukemia cells. Mol Cell Biol 17 , 4272-4281.
1997-2



1996

Ueno H, Sasaki K, Kozutsumi H, Miyagawa K, Mitani K, Yazaki Y, and Hirai H. (1996) Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase. J Biol Chem 271 , 27707-27714.



1995

▶ Odai H, Sasaki K, Hanazono Y, Ueno H, Tanaka T, Miyagawa K, Mitani K, Yazaki Y, and Hirai H. (1995) c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed fibroblasts. Cancer Science (formerly Jpn J Cancer Res) 86 , 1119-1126.

▶ Sasaki K, Odai H, Hanazono Y, Ueno H, Ogawa S, Langdon WY, Tanaka T, Miyagawa K, Mitani K, Yazaki Y, and et al. (1995) TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules. Biochem Biophys Res Commun 216 , 338-347.
1995

Ueno H, Hirano N, Kozutsumi H, Sasaki K, Tanaka T, Yazaki Y, and Hirai H. (1995) An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway. J Biol Chem 270 , 20135-20142.



kokunai

▶ 2018年6月, 厚海 奈穂・上野 博夫,BIOLOGY TOPICS 乳がんの起原とクローン進化の解明 - 多色細胞系譜追跡法によるアプローチ , 「BIO Clinica 2018年 6月号」 ISSN 09198237
BIO Clinica 2018 6月号

▶ 2017年2月, 厚海 奈穂・上野 博夫,BIOLOGICAL TOPICS 多色細胞系譜追跡法を通した乳がん幹細胞の探索―不均一性を生じるクローン進化の解明に向けて , 「BIO Clinica 2017年 2月号」 17(2), ISSN 17601-02
BIO Clinica 2017年 2月号

▶ 2016年6月, 上野 博夫, REVIEW 多色細胞系譜追跡法と幹細胞研究, 「再生医療」15(2):15-31, ISSN 1347-7919
再生医療

▶ 2015年7月, 厚海奈穂,上野 博夫, 技術講座 マルチカラー細胞系譜追跡法, 「細胞」7月号, 47(7):54
細胞

▶ 2014年1月, 上野 博夫, 1枚の写真館 マルチカラー細胞系譜追跡法と舌, 「細胞工学」1月号, 33(1):7
細胞工学

▶ 2011年12月, 上野 博夫, がん幹細胞性 第2章 固形腫瘍幹細胞 3.正常腸上皮細胞の発生およびがん化過程におけるclonality解析, 「実験医学増刊」12月号, 29(20):3262-3268
jikkenigaku

▶ 2011年11月, 上野 博夫, 癌幹細胞の実態と治療戦略 2.病態 1)正常と癌の幹細胞, 「医薬ジャーナル」11月号, 47(11):2693-2697
iyaku

▶ 2007年3月, 上野 博夫, マルチカラーキメラ胚を用いた哺乳類発生系譜の解析法, 「バイオテクノロジージャーナル」3月号, 7(2):212-216
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